Rabbit anti-Human FOXE2 Polyclonal Antibody | anti-FOXE1 antibody

FOXE2 (Forkhead Box E2, HFKH4, HNF-3 Forkhead-Like Protein 5, HFKL5)

Cat. Num. AAA612918

• Gene Names: FOXE1; TTF2; FOXE2; HFKH4; HFKL5; TITF2; TTF-2; FKHL15
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: FOXE2; Polyclonal Antibody; FOXE2 (Forkhead Box E2; HFKH4; HNF-3 Forkhead-Like Protein 5; HFKL5); Anti -FOXE2 (Forkhead Box E2; anti-FOXE1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FOXE2.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, sodium azide, before the addition of glycerol to 40%.

• Applicable Applications for anti-FOXE1 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA Titer: 1:250,000.
• Immunogen: Synthetic peptide (C-DQLQPPQPRDHFRTPR) corresponding to human FOXE2 (KLH). Molecular Weight: 52.3kD
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-FOXE1 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 21618325
• NCBI GeneID: 2304
• NCBI Accession #: NP_004464.2
• NCBI GenBank Nucleotide #: NM_004473.3
• UniProt Accession #: O00358; O75765; Q5T109; Q99526
• Molecular Weight: 38,076 Da
• NCBI Official Full Name: forkhead box protein E1
• NCBI Official Synonym Full Names: forkhead box E1 (thyroid transcription factor 2)
• NCBI Official Symbol: FOXE1
• NCBI Official Synonym Symbols: TTF2; FOXE2; HFKH4; HFKL5; TITF2; TTF-2; FKHL15
• NCBI Protein Information: forkhead box protein E1; forkhead box E2; OTTHUMP00000021756; forkhead box protein E2; HNF-3/fork head-like protein 5; thyroid transcription factor 2; forkhead-related protein FKHL15; forkhead, drosophila, homolog-like 15
• UniProt Protein Name: Forkhead box protein E1
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXE1
• UniProt Synonym Gene Names: FKHL15; FOXE2; TITF2; TTF2
• UniProt Entry Name: FOXE1_HUMAN

NCBI Description

This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. [provided by RefSeq]

Uniprot Description

FOXE1: Probable transcription factor. Could be involved in thyroid gland organogenesis. Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome (BLS). BLS is associated with thyroid agenesis, cleft palate and choanal atresia.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: nucleus

Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; cell migration; anatomical structure morphogenesis; hair follicle morphogenesis; thymus development; positive regulation of transcription, DNA-dependent; thyroid hormone generation; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; embryonic organ morphogenesis; hard palate development; thyroid gland development; soft palate development; negative regulation of transcription, DNA-dependent

Disease: Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate; Thyroid Cancer, Nonmedullary, 4