Mouse anti-Human HCC-4 Monoclonal Antibody | anti-HCC-4 antibody

HCC-4 (C-C motif chemokine 16 CCL16, Chemokine CC-4, CKb12, HCC-4, IL-10-inducible chemokine (ILINCK), LCC-1, Liver-expressed chemokine (Chemokine LEC), Lymphocyte and monocyte chemoattractant (LMC), Monotactin-1 (MTN-1), New CC chemokine 4 (NCC-4), SCYL4

Cat. Num. AAA6123201

• Gene Names: CCL16; LEC; LMC; NCC4; CKb12; HCC-4; LCC-1; Mtn-1; NCC-4; SCYL4; ILINCK; SCYA16
• Reactivity: Human
• Applications: FLISA
• Purity: Purified by Protein A/G Affinity Chromatography.
• Synonyms: HCC-4; Monoclonal Antibody; HCC-4 (C-C motif chemokine 16 CCL16; Chemokine CC-4; CKb12; IL-10-inducible chemokine (ILINCK); LCC-1; Liver-expressed chemokine (Chemokine LEC); Lymphocyte and monocyte chemoattractant (LMC); Monotactin-1 (MTN-1); New CC chemokine 4 (NCC-4); SCYL4; C-C motif chemokine 16 CCL16; Small-inducible cytokine A16; SCYA16; anti-HCC-4 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: LEC66
• Specificity: Recognizes human HCC-4.
• Purity/Purification: Purified by Protein A/G Affinity Chromatography.
• Form/Format: Supplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Labeled with Fluorescein isothiocyanate (FITC).

• Applicable Applications for anti-HCC-4 antibody: FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Recombinant human HCC-4 protein. Cellular Localization: Secreted (extracellular)
• Conjugate: FITC
• Positive Control: Liver, spleen and thymus
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer.; ; FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Categories/Family for anti-HCC-4 antibody

Antibodies; Growth Factors; Cytokines

References

1. Hedrick, J.A., Helms, A., Vicari, A. and Zlotnik, A. 1998. Characterization of a novel C-C chemokine, HCC-4, whose expression is increased by inter- leukin-10. Blood 91: 4242-4247.

NCBI and Uniprot Product Information

• NCBI GI #: 4759074
• NCBI GeneID: 6360
• NCBI Accession #: NP_004581.1
• NCBI GenBank Nucleotide #: NM_004590.3
• UniProt Accession #: O15467; Q4KKU0
• Molecular Weight: 13,600 Da
• NCBI Official Full Name: C-C motif chemokine 16
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 16
• NCBI Official Symbol: CCL16
• NCBI Official Synonym Symbols: LEC; LMC; NCC4; CKb12; HCC-4; LCC-1; Mtn-1; NCC-4; SCYL4; ILINCK; SCYA16
• NCBI Protein Information: C-C motif chemokine 16; IL-10-inducible chemokine; chemokine LEC; liver CC chemokine-1; liver-expressed chemokine; lymphocyte and monocyte chemoattractant; monotactin-1; new CC chemokine 4; small inducible cytokine subfamily A (Cys-Cys), member 16; small-
• UniProt Protein Name: C-C motif chemokine 16
• UniProt Gene Name: CCL16
• UniProt Synonym Gene Names: ILINCK; NCC4; SCYA16; HCC-4; LMC; MTN-1
• UniProt Entry Name: CCL16_HUMAN

NCBI Description

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]

Uniprot Description

CCL16: Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Chemokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; chemoattractant activity

Biological Process: cell-cell signaling; positive chemotaxis; cell communication; immune response; chemotaxis; inflammatory response