Rabbit Iron Responsive Element Binding Protein 2 Polyclonal Antibody | anti-IREB2 antibody
Iron Responsive Element Binding Protein 2 (IREB2, IREBP2, ACO3, FLJ23381, Iron Regulatory Protein 2, IRP2, IRP2AD)
Gene Names
IREB2; ACO3; IRP2; IRP2AD; FLJ23381
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
Iron Responsive Element Binding Protein 2; Polyclonal Antibody; Iron Responsive Element Binding Protein 2 (IREB2; IREBP2; ACO3; FLJ23381; Iron Regulatory Protein 2; IRP2; IRP2AD); Anti -Iron Responsive Element Binding Protein 2 (IREB2; anti-IREB2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
Species Crossreactivity: This antibody reacts with mouse IRP2 protein. Inital results have shown poor reactivity against human protein. The immunogen used for this antibody production has 94% homology with human and rat proteins.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Tris-glycine and 150mM NaCl containing 0.05% sodium azide.
Applicable Applications for anti-IREB2 antibody
Western Blot (WB)
Application Notes
Suitable for use in Western Blot.
Immunogen
A synthetic peptide made to an internal portion of the murine IRP2 protein sequence (between residues 100-200). UniProt Q811J3.
Cellular Localization
Cytoplasmic
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-IREB2 antibody
Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis.
Product Categories/Family for anti-IREB2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
105,045 Da
NCBI Official Full Name
iron-responsive element-binding protein 2
NCBI Official Synonym Full Names
iron-responsive element binding protein 2
NCBI Official Symbol
IREB2
NCBI Official Synonym Symbols
ACO3; IRP2; IRP2AD; FLJ23381
NCBI Protein Information
iron-responsive element-binding protein 2; IRE-BP 2; OTTHUMP00000185022; iron regulatory protein 2
UniProt Protein Name
Iron-responsive element-binding protein 2
Protein Family
UniProt Gene Name
IREB2
UniProt Entry Name
IREB2_HUMAN
Uniprot Description
IREB2: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. Belongs to the aconitase/IPM isomerase family.
Protein type: RNA-binding; Translation
Chromosomal Location of Human Ortholog: 15q25.1
Cellular Component: mitochondrion; cytoplasm; cytosol
Molecular Function: iron-responsive element binding; protein binding; translation repressor activity; RNA binding; 4 iron, 4 sulfur cluster binding; metal ion binding
Biological Process: erythrocyte homeostasis; response to retinoic acid; cellular iron ion homeostasis; negative regulation of translation; osteoclast differentiation; response to iron(II) ion; protoporphyrinogen IX biosynthetic process; iron ion transport; intestinal absorption; post-embryonic development; aging
Research Articles on IREB2
Similar Products
Product Notes
The IREB2 ireb2 (Catalog #AAA612109) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Iron Responsive Element Binding Protein 2 (IREB2, IREBP2, ACO3, FLJ23381, Iron Regulatory Protein 2, IRP2, IRP2AD) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Iron Responsive Element Binding Protein 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the IREB2 ireb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Iron Responsive Element Binding Protein 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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