Rabbit DUSP18 Polyclonal Antibody | anti-DUSP18 antibody

DUSP18 (Dual Specificity Phosphatase 18, DUSP-18)

Cat. Num. AAA610811

• Gene Names: DUSP18; DSP18; DUSP20; LMWDSP20; MGC32658; bK963H5.1
• Reactivity: Bovine, Human, Monkey
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: DUSP18; Polyclonal Antibody; DUSP18 (Dual Specificity Phosphatase 18; DUSP-18); Anti -DUSP18 (Dual Specificity Phosphatase 18; anti-DUSP18 antibody

• Host: Rabbit
• Reactivity: Bovine, Human, Monkey
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: The amino acid sequence used as immunogen is 100% homologous in human, rhesus monkey, chimp, orangutan and bovine, 92% homologous in canine and 85% homologous in rat. Species Crossreactivity: Bovine, Chimpanzee, Human, Orangutan, Rhesus Monkey
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.

• Applicable Applications for anti-DUSP18 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blotting: 1:1000-1:2000
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-DUSP18 antibody

Antibodies; Abs to Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 51093845
• NCBI GeneID: 150290
• NCBI Accession #: NP_689724.3
• NCBI GenBank Nucleotide #: NM_152511.3
• UniProt Accession #: Q8NEJ0; B3KPA4
• Molecular Weight: 21,066 Da
• NCBI Official Full Name: dual specificity protein phosphatase 18
• NCBI Official Synonym Full Names: dual specificity phosphatase 18
• NCBI Official Symbol: DUSP18
• NCBI Official Synonym Symbols: DSP18; DUSP20; LMWDSP20; MGC32658; bK963H5.1
• NCBI Protein Information: dual specificity protein phosphatase 18; LMW-DSP20; OTTHUMP00000199179; low molecular weight dual specificity phosphatase 20
• UniProt Protein Name: Dual specificity protein phosphatase 18
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP18
• UniProt Synonym Gene Names: LMWDSP20
• UniProt Entry Name: DUS18_HUMAN

NCBI Description

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM]

Uniprot Description

DUSP18: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; EC 3.1.3.48; Mitochondrial; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process: inactivation of MAPK activity