Rabbit Glucose Regulated Protein 78 Polyclonal Antibody
Glucose Regulated Protein 78 (Grp78, BiP)
Reactivity
Bovine, Hamster, Monkey, Mouse, Rabbit, Rat, Xenopus
Applications
Western Blot
Purity
Affinity PurifiedPurified by Protein A affinity chromatography.
Synonyms
Glucose Regulated Protein 78; Polyclonal Antibody; Glucose Regulated Protein 78 (Grp78; BiP); Anti -Glucose Regulated Protein 78 (Grp78; anti-Glucose Regulated Protein 78 antibody
Host
Rabbit
Reactivity
Bovine, Hamster, Monkey, Mouse, Rabbit, Rat, Xenopus
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes rat Grp78 at ~78kD Species Crossreactivity: mouse, bovine, hamster, monkey, rabbit, Xenopus, and fungus (Cryphonectria parasitica).
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol
Applicable Applications for anti-Glucose Regulated Protein 78 antibody
Western Blot (WB)
Application Notes
Suitable for use in Western Blot.
Dilution: Western Blot (ECL): 1:1000
Positive Controls:
G3057-22: Recombinant Hamster Grp78 Protein.
Dilution: Western Blot (ECL): 1:1000
Positive Controls:
G3057-22: Recombinant Hamster Grp78 Protein.
Immunogen
Synthetic peptide corresponding to aa 645-654 of rat Grp78 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-Glucose Regulated Protein 78 antibody
Grp78, a 78kD glucose-regulated protein, also known as BiP or immunoglobulin heavy chain binding protein, is a stress-response protein which is induced by agents or conditions that adversely affect endoplasmic reticulum (ER) function (2). This protein is essential for the proper glycosylation, folding and assembly of many membrane bound and secreted proteins (3). Grp78 is critical for maintenance of cell homeostasis and the prevention of apoptosis (4). Grp78 protein levels have been shown to be a reliable biomarker of hypoglycermia (5) as well as serving a neuroprotective function in neurons exposed to glutamate and oxidative stress (2). Grp78 levels are reduced in the brains of Alzheimer's Disease patients and decreased expression of Grp78 is found associated with missense mutations in the human presenilin-1 (PS1) gene (6). The induction of the Grp78 protein has been associated with the development of drug-resistance to anti-tumor drugs (7).
Product Categories/Family for anti-Glucose Regulated Protein 78 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI Official Full Name
glucose-regulated protein 78
Similar Products
Product Notes
The Glucose Regulated Protein 78 (Catalog #AAA610773) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Glucose Regulated Protein 78 (Grp78, BiP) reacts with Bovine, Hamster, Monkey, Mouse, Rabbit, Rat, Xenopus and may cross-react with other species as described in the data sheet. AAA Biotech's Glucose Regulated Protein 78 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot (ECL): 1:1000 Positive Controls: G3057-22: Recombinant Hamster Grp78 Protein. Researchers should empirically determine the suitability of the Glucose Regulated Protein 78 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Glucose Regulated Protein 78, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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