Mouse HLA Class 2 Antigen DQw1 Monoclonal Antibody | anti-HLA-DQA1 antibody

HLA Class 2 Antigen DQw1 (HLA DQw1 Class II, HLA-DQw1)

Cat. Num. AAA609112

• Gene Names: HLA-DQA1; CD; GSE; DQ-A1; CELIAC1; HLA-DQA
• Applications: Immunofluorescence
• Purity: Ascites; Ascites
• Synonyms: HLA Class 2 Antigen DQw1; Monoclonal Antibody; HLA Class 2 Antigen DQw1 (HLA DQw1 Class II; HLA-DQw1); Anti -HLA Class 2 Antigen DQw1 (HLA DQw1 Class II; anti-HLA-DQA1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: IIB3
• Specificity: Recognizes a polymorphic determinant on DQ-like molecules which is associated with DR1, DR2 and DRw6. Reacts with a part of the DR4, DR7, DRw8 and DRw9 positive cells. The determinant is strongly expressed on DR2, DR4 and DRw6 positive cells but only weakly on DR1 and DR7 positive cells. Reacts mainly with B-lymphocytes.
• Purity/Purification: Ascites; Ascites
• Form/Format: Supplied as a liquid, sodium azide.

• Applicable Applications for anti-HLA-DQA1 antibody: Immunofluorescence (IF)
• Application Notes: Suitable for use Immunofluorescence and Microcytotoxicity.; Dilution: Immunofluorescence: 1:10 diltuted in PBS, 1% BSA, 0.01% sodium azide.; Microcytotoxicity: 1:10 diltuted in PBS, 1% BSA, 0.01% sodium azide.
• Immunogen: HLA Class 2 Antigen DQw1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Categories/Family for anti-HLA-DQA1 antibody

Antibodies; Abs to HLA

NCBI and Uniprot Product Information

• NCBI GI #: 18426975
• NCBI GeneID: 3117
• NCBI Accession #: NP_002113.2
• NCBI GenBank Nucleotide #: NM_002122.3
• UniProt Accession #: P01909; O19630; O19706; P01907; P01908; P04225; P04226; P05536; P79553; Q06751; Q29876; Q29994
• Molecular Weight: 27,805 Da
• NCBI Official Full Name: HLA class II histocompatibility antigen, DQ alpha 1 chain
• NCBI Official Synonym Full Names: major histocompatibility complex, class II, DQ alpha 1
• NCBI Official Symbol: HLA-DQA1
• NCBI Official Synonym Symbols: CD; GSE; DQ-A1; CELIAC1; HLA-DQA
• NCBI Protein Information: HLA class II histocompatibility antigen, DQ alpha 1 chain; HLA-DCA; DC-alpha; DC-1 alpha chain; MHC HLA-DQ alpha; MHC class II DQA1; MHC class II antigen; leucocyte antigen DQA1; MHC class II HLA-DQ-alpha-1; leukocyte antigen alpha chain; MHC class II surface glycoprotein; MHC class II HLA-D alpha glycoprotein; HLA class II histocompatibility antigen, DQ(W3) alpha chain
• UniProt Protein Name: HLA class II histocompatibility antigen, DQ alpha 1 chain
• Protein Family: HLA class II histocompatibility antigen
• UniProt Gene Name: HLA-DQA1
• UniProt Entry Name: DQA1_HUMAN

NCBI Description

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]

Uniprot Description

HLA-DQA1 iso4:

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; membrane; integral to plasma membrane; lysosomal membrane; plasma membrane; endosome membrane; trans-Golgi network membrane; external side of plasma membrane; MHC class II protein complex

Molecular Function: MHC class II receptor activity; peptide antigen binding

Biological Process: positive regulation of T cell differentiation; cytokine and chemokine mediated signaling pathway; T cell costimulation; antigen processing and presentation of exogenous peptide antigen via MHC class II; immune response; T cell receptor signaling pathway