Mouse anti-Human CDC42 Binding Protein Kinase alpha Monoclonal Antibody | anti-CDC42BPA antibody

CDC42 Binding Protein Kinase alpha (CDC42-binding Protein Kinase alpha, DMPK-like alpha, CDC42BPA, FLJ23347, KIAA0451, Myotonic Dystrophy Kinase-related CDC42-binding Kinase alpha, Myotonic Dystrophy Protein Kinase-like alpha, Serine/threonine-protein Kin

Cat. Num. AAA606191

• Gene Names: CDC42BPA; MRCK; MRCKA; PK428; FLJ23347; KIAA0451; DKFZp686L1738; DKFZp686P1738; CDC42BPA
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: CDC42 Binding Protein Kinase alpha; Monoclonal Antibody; CDC42 Binding Protein Kinase alpha (CDC42-binding Protein Kinase alpha; DMPK-like alpha; CDC42BPA; FLJ23347; KIAA0451; Myotonic Dystrophy Kinase-related CDC42-binding Kinase alpha; Myotonic Dystrophy Protein Kinase-like alpha; Serine/threonine-protein Kin; Anti -CDC42 Binding Protein Kinase alpha (CDC42-binding Protein Kinase alpha; anti-CDC42BPA antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 10B2176
• Specificity: Recognizes human CDC42BPA.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free).

• Applicable Applications for anti-CDC42BPA antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 1:500-1:1000; ELISA: 1ug/ml-3ng/ml
• Immunogen: Recombinant protein corresponding to a portion of amino acids within aa551-650 of human CDC42BPA.
• Hybridoma: Sp2/0 myeloma cells with spleen cells from Balb/c mice.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-CDC42BPA antibody

The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.

Product Categories/Family for anti-CDC42BPA antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 29373942
• NCBI GeneID: 8476
• UniProt Accession #: Q5VT25; Q5HYB0; Q5T799; Q5T7A0; Q5T7A7; Q8IWQ7; Q9H5K7; Q9NYF6
• Molecular Weight: 186,038 Da
• NCBI Official Full Name: CDC42 binding protein kinase alpha (DMPK-like)
• NCBI Official Synonym Full Names: CDC42 binding protein kinase alpha (DMPK-like)
• NCBI Official Symbol: CDC42BPA
• NCBI Official Synonym Symbols: MRCK; MRCKA; PK428; FLJ23347; KIAA0451; DKFZp686L1738; DKFZp686P1738; CDC42BPA
• NCBI Protein Information: serine/threonine-protein kinase MRCK alpha; DMPK-like alpha; OTTHUMP00000035730; ser-thr protein kinase PK428; CDC42 binidng protein kinase beta; myotonic dystrophy protein kinase-like alpha; CDC42-binding protein kinase alpha (DMPK-like); myotonic dystrophy kinase-related CDC42-binding kinase alpha; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; ser-thr protein kinase related to the myotonic dystrophy protein kinase
• UniProt Protein Name: CDC42-binding protein kinase beta
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: CDC42BPA
• UniProt Entry Name: Q8IWQ7_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq]

Uniprot Description

MRCKA: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, AGC; AGC group; DMPK family; GEK subfamily

Chromosomal Location of Human Ortholog: 1q42.11

Cellular Component: leading edge; cytoplasm; actomyosin; intercellular junction

Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; magnesium ion binding; ATP binding

Biological Process: cell migration; regulation of catalytic activity; actomyosin structure organization and biogenesis; actin cytoskeleton reorganization; microtubule cytoskeleton organization and biogenesis; protein amino acid phosphorylation; nuclear migration