Mouse Vanilloid Receptor Like Protein 3 Monoclonal Antibody | anti-TRPV3 antibody

Vanilloid Receptor Like Protein 3 (Vanilloid Receptor-like 3, VRL 3, VRL-3, VRL3, HGNC:18084, Transient Receptor Potential Cation Channel Subfamily V Member 3, Trpv3 Heat Sensitive Channel, TRPV3)

Cat. Num. AAA606078

• Gene Names: TRPV3; VRL3; TRPV3
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunoprecipitation, Immunocytochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Vanilloid Receptor Like Protein 3; Monoclonal Antibody; Vanilloid Receptor Like Protein 3 (Vanilloid Receptor-like 3; VRL 3; VRL-3; VRL3; HGNC:18084; Transient Receptor Potential Cation Channel Subfamily V Member 3; Trpv3 Heat Sensitive Channel; TRPV3); Anti -Vanilloid Receptor Like Protein 3 (Vanilloid Receptor-like 3; anti-TRPV3 antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 10F779
• Specificity: Recognizes rat TrpV3. Species Crossreactivity: human.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide and 50% glycerol.

• Applicable Applications for anti-TRPV3 antibody: Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry.; Dilution: Western Blot: 1-10ug/ml; Immunocytochemistry: 0.1-1ug/ml
• Immunogen: Synthetic peptide corresponding to aa 458-474 (cytoplasmic C-terminus) of rat TrpV3 accession number NP_001020928).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-TRPV3 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). The TRPV3 protein belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. The gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels (3, 4).

Product Categories/Family for anti-TRPV3 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 22651775
• NCBI GeneID: 162514
• UniProt Accession #: Q2M3L1; Q8NET8; Q8TET8
• Molecular Weight: 90,593 Da
• NCBI Official Full Name: vanilloid receptor like 3 protein splice variant a
• NCBI Official Synonym Full Names: transient receptor potential cation channel, subfamily V, member 3
• NCBI Official Symbol: TRPV3
• NCBI Official Synonym Symbols: VRL3; TRPV3
• NCBI Protein Information: transient receptor potential cation channel subfamily V member 3; VRL-3; vanilloid receptor 3; vanilloid receptor-like 3; vanilloid receptor-related osmotically activated channel protein
• UniProt Protein Name: TRPV3 protein
• Protein Family: Transient receptor potential cation channel subfamily
• UniProt Gene Name: TRPV3
• UniProt Entry Name: Q2M3L1_HUMAN

NCBI Description

This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. [provided by RefSeq]

Uniprot Description

TRPV3: Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). May form a heteromeric channel with TRPV1. Interacts with TRPV1. Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion. Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: integral to membrane; plasma membrane; receptor complex

Molecular Function: calcium channel activity

Biological Process: negative regulation of hair cycle; response to heat; transmembrane transport

Disease: Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques; Palmoplantar Keratoderma, Nonepidermolytic, Focal 2