Mouse anti-Human Integrin beta6 Monoclonal Antibody | anti-ITGB6 antibody

Integrin beta6

Cat. Num. AAA603792

• Gene Names: ITGB6; ITGB6
• Reactivity: Human
• Applications: Flow Cytometry, Immunoprecipitation, Immunocytochemistry, Immunohistochemistry, Western Blot
• Purity: Affinity Purified; Purified by affinity chromatography from ascites.
• Synonyms: Integrin beta6; Monoclonal Antibody; Anti -Integrin beta6; anti-ITGB6 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 2Q791
• Specificity: Recognizes human Integrin beta6.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography from ascites.
• Form/Format: Supplied as a liquid in PBS, pH 7.1. No preservatives added.
• Concentration: 1 mg/mL (varies by lot)

• Applicable Applications for anti-ITGB6 antibody: Suitable for use in Flow Cytometry, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Not suitable for use in Function Blocking or Western Blot. Other applications have not been tested.
• Application Notes: Immunoprecipitation : Because MBS603792 is and IgG2a, protein Gor rabbit anti-mouse IgG is helpful for capture.; ; Immunohistochemistry & Immunocytochemistry: Acetone fixed , Nuclear background staining limits usefulnesss in these techniques. ; ; Optimal dilution to be determined by researcher.
• Immunogen: Murine NIH 3T3 cells stably transfected with the human b6 subunit.
• Preparation and Storage: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-ITGB6 antibody

Integrins are a large family of transmembrane proteins composed of an alpha and beta component. Integrins are involved in a diversity of biological functions such as cell adhesion, structure, differentiation, apoptosis and cell proliferation. They are the principal cell surface receptors that recognise cell to matrix interactions but little is known about the expression of beta 1 integrin family on airway smooth muscle (ASM) and their involvement in proliferation. This is a contributing factor in structural changes seen in asthma.

Product Categories/Family for anti-ITGB6 antibody

Antibodies; Abs to Integrin

NCBI and Uniprot Product Information

• NCBI GI #: 9625002
• NCBI GeneID: 3694
• NCBI Accession #: NP_000879.2
• NCBI GenBank Nucleotide #: NM_000888.3
• UniProt Accession #: P18564; Q0VA95; Q16500; Q53RG5; Q53RR6; B2R9W5
• NCBI Official Full Name: integrin beta-6
• NCBI Official Synonym Full Names: integrin, beta 6
• NCBI Official Symbol: ITGB6
• NCBI Official Synonym Symbols: ITGB6
• NCBI Protein Information: integrin beta-6; OTTHUMP00000162896; OTTHUMP00000205127; OTTHUMP00000205128; OTTHUMP00000207333
• UniProt Protein Name: Integrin beta-6
• Protein Family: Integrin
• UniProt Gene Name: ITGB6
• UniProt Entry Name: ITB6_HUMAN

NCBI Description

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

ITGB6: Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Belongs to the integrin beta chain family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 2q24.2

Cellular Component: plasma membrane; integrin complex; receptor complex; external side of plasma membrane

Molecular Function: integrin binding; viral receptor activity

Biological Process: integrin-mediated signaling pathway; entry of virus into host cell; extracellular matrix organization and biogenesis; multicellular organismal development; cell-matrix adhesion; cell adhesion; inflammatory response

Disease: Amelogenesis Imperfecta, Type Ih