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Mouse Ornithine Decarboxylase Monoclonal Antibody | anti-ODC1 antibody

Ornithine Decarboxylase (ODC, Dodc1, Ornithine Decarboxylase 1, Odc1, Ornithine Decarboxylase 2, ODC2, ODCP, Ornithine Decarboxylase Structural 1, RNODC) (BSA & Azide Free)

Gene Names
ODC1; ODC
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry
Purity
Affinity Purified
Purified by Protein G affinity chromatography.
Synonyms
Ornithine Decarboxylase; Monoclonal Antibody; Ornithine Decarboxylase (ODC; Dodc1; Ornithine Decarboxylase 1; Odc1; Ornithine Decarboxylase 2; ODC2; ODCP; Ornithine Decarboxylase Structural 1; RNODC) (BSA & Azide Free); Anti -Ornithine Decarboxylase (ODC; anti-ODC1 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3F293
Specificity
Recognizes native rat ODC and not the inhibited (labeled with H3-DFMO) enzyme. Species Crossreactivity: Human, mouse. Expected to crossreact with ODC from other eukaryotic cells.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.4. Also available with BSA and azide. See O8025-15.
Applicable Applications for anti-ODC1 antibody
Immunohistochemistry (IHC)
Application Notes
Suitable for use in Immunohistochemistry. Not suitable for use in Western Blot.
Dilution: Immunohistochemistry: Frozen sections
Immunogen
Synthetic hexadecapeptide (aa345-360, KPDEKYYSSSIWGPTC) from rat ODC. MW of Antigen: 53kD Epitope: aa355-360 (-IWGPTC-). It is associated with active site of ODC or a locus in its direct vicinity. Cellular Localization: Cytoplasmic.
Positive Control
Epithelial cells in normal placenta or prostate carcinoma.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-ODC1 antibody
ODC is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines. It is involved in the conversion of ornithine to putrescine. The biological activity of ODC is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas, colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.
Product Categories/Family for anti-ODC1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
51,148 Da
NCBI Official Full Name
ornithine decarboxylase
NCBI Official Synonym Full Names
ornithine decarboxylase 1
NCBI Official Symbol
ODC1
NCBI Official Synonym Symbols
ODC
NCBI Protein Information
ornithine decarboxylase; OTTHUMP00000115512; OTTHUMP00000200387
UniProt Protein Name
Ornithine decarboxylase
Protein Family
UniProt Gene Name
ODC1
UniProt Entry Name
DCOR_HUMAN

NCBI Description

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq]

Uniprot Description

ODC: the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq, Jul 2008]

Protein type: EC 4.1.1.17; Other Amino Acids Metabolism - glutathione; Lyase; Amino Acid Metabolism - arginine and proline; Cell cycle regulation

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: cytoplasm; cytosol

Molecular Function: protein homodimerization activity; ornithine decarboxylase activity

Biological Process: response to virus; positive regulation of cell proliferation; regulation of protein catabolic process; kidney development; regulation of amino acid metabolic process; putrescine biosynthetic process from ornithine; polyamine metabolic process

Disease: Colorectal Cancer

Research Articles on ODC1

Similar Products

Product Notes

The ODC1 odc1 (Catalog #AAA602385) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Ornithine Decarboxylase (ODC, Dodc1, Ornithine Decarboxylase 1, Odc1, Ornithine Decarboxylase 2, ODC2, ODCP, Ornithine Decarboxylase Structural 1, RNODC) (BSA & Azide Free) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Ornithine Decarboxylase can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Suitable for use in Immunohistochemistry. Not suitable for use in Western Blot. Dilution: Immunohistochemistry: Frozen sections. Researchers should empirically determine the suitability of the ODC1 odc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ornithine Decarboxylase, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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