CUG-Binding Protein 1 Monoclonal Antibody | anti-CELF1 antibody

Anti - CUG-Binding Protein 1 (CUG-BPI, Cytidine Uridine Guanosine Binding Protein 1)

Cat. Num. AAA601578

• Gene Names: CELF1; CUGBP; NAB50; NAPOR; CUG-BP; CUGBP1; hNab50; BRUNOL2; EDEN-BP
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Purified immunoglobulin
• Synonyms: CUG-Binding Protein 1; Monoclonal Antibody; Anti - CUG-Binding Protein 1 (CUG-BPI; Cytidine Uridine Guanosine Binding Protein 1); CUG-Binding Protein 1 (CUG-BPI; anti-CELF1 antibody

• Host: Host: Mouse; Source: Rat
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 7C23
• Specificity: Reacts with rat CUGBP1. Species Crossreactivity: Mouse and human.
• Purity/Purification: Purified immunoglobulin
• Form/Format: Purified; Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%.
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-CELF1 antibody: ELISA, Western Blot
• Application Notes: ELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/ml.; Western Blot: 1:1000-1:5000 using ECL technique.
• Immunogen: Purified rat CUG-BP1 protein
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-CELF1 antibody

RNA editing is an important mechanism for regulating genetic plasticity through the generation of alternative protein productsfrom a single structural gene. Substitutional RNA editing employsa variety of genetic mechanisms, the biochemical basis of whichhas been elucidated following the development of in vitro assaysthat recapitulate important elements of this process. There are two typesof substitutional RNA exist in mammals, namely A-to-I and C-to-URNA editing. The best-characterized example of C-to-U RNA editing involves the nuclear transcript encoding intestinal apolipoprotein B(apo B)). Apo B RNA editing changes a CAA to a UAA stop codon,generating a truncated protein, apoB48. The functional complex includes a minimal corecomposed of apobec-1 and ACF, that functionas an adaptor protein by binding both the deaminase and the RNAsubstrate. The RNA binding proteins also include CUGBP2 which along with Apobec-1 binds to the consensus binding sequence UUUN (A/U) U, present in c-myc, VEGF and Cyclooxygenase-2 (COX2).

Product Categories/Family for anti-CELF1 antibody

Abs to Proteins

References

• Timchecnko et al (1996) Nucl Acid Res. 24, 4407-4414; Good PJ et al (2000) JBC 275, 28583; Strasuberg R et al (2002) PNAS 99, 16899; Timchenko NA et al (1999) Nucl Acid Res. 27, 4517;

NCBI and Uniprot Product Information

• NCBI GI #: 5729794
• NCBI GeneID: 10658
• NCBI Accession #: NP_006551.1
• NCBI GenBank Nucleotide #: NM_006560.3
• UniProt Accession #: Q92879; Q4LE52; Q9NP83; Q9NR06; D3DQS0
• Molecular Weight: 52,063 Da
• NCBI Official Full Name: CUGBP Elav-like family member 1 isoform 1
• NCBI Official Synonym Full Names: CUGBP, Elav-like family member 1
• NCBI Official Symbol: CELF1
• NCBI Official Synonym Symbols: CUGBP; NAB50; NAPOR; CUG-BP; CUGBP1; hNab50; BRUNOL2; EDEN-BP
• NCBI Protein Information: CUGBP Elav-like family member 1; CELF-1; CUG-BP1; bruno-like 2; EDEN-BP homolog; OTTHUMP00000233203; OTTHUMP00000233204; OTTHUMP00000233205; OTTHUMP00000238034; OTTHUMP00000238035; OTTHUMP00000238036; bruno-like protein 2; CUG RNA-binding protein; deadenylation factor CUG-BP; RNA-binding protein BRUNOL-2; CUG-BP- and ETR-3-like factor 1; CUG triplet repeat RNA-binding protein 1; CUG triplet repeat, RNA binding protein 1; CUG triplet repeat, RNA-binding protein 1; embryo deadenylation element binding protein; 50 kDa nuclear polyadenylated RNA-binding protein; nuclear polyadenylated RNA-binding protein, 50-kD; embryo deadenylation element-binding protein homolog
• UniProt Protein Name: CUGBP Elav-like family member 1
• Protein Family: CUGBP Elav-like family
• UniProt Gene Name: CELF1
• UniProt Synonym Gene Names: BRUNOL2; CUGBP; CUGBP1; NAB50
• UniProt Entry Name: CELF1_HUMAN