Mouse anti-Human Amyloid A4, Variant 40 Monoclonal Antibody | anti-APBB2 antibody

Amyloid A4, Variant 40, CT (Amyloid beta)

Cat. Num. AAA6013099

• Gene Names: APBB2; FE65L; FE65L1
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Amyloid A4; Variant 40; Monoclonal Antibody; CT (Amyloid beta); Anti -Amyloid A4; anti-APBB2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 12K246
• Specificity: Recognizes the C-terminal of human beta amyloid peptide 40, and full length beta amyloid peptide 40.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a lyophilized powder from 0.01M PBS, pH7.2. Reconstitute with ddH2O to 1mg/ml.

• Applicable Applications for anti-APBB2 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.
• Immunogen: Synthetic peptide corresponding to the C-terminal (GLMVGGVV) of human beta amyloid peptide 40 (KLH).
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-APBB2 antibody

Alzheimers disease (AD) is characterized by the presence of senile plaques in the brain and blood vessel walls. Amyloid Beta A4 (Ab4) protein has been found to be the principal constituent of senile plaques of ADs patients. The amyloid beta-protein precursor (APP) is proteolytically cleaved to generate the 4kD Ab4 protein. Two variants of Ab4 can be detected; Ab-40 short-tailed and Ab-42 long-tailed.

Product Categories/Family for anti-APBB2 antibody

Antibodies; Abs to Amyloid

NCBI and Uniprot Product Information

• NCBI GI #: 260593731
• NCBI GeneID: 323
• NCBI Accession #: NP_001159522.1
• NCBI GenBank Nucleotide #: NM_001166050.1
• UniProt Accession #: Q92870; Q8IUI6; B4DSL4; E9PG87
• Molecular Weight: 83,374 Da
• NCBI Official Full Name: amyloid beta A4 protein-binding family B member 2 isoform b
• NCBI Official Synonym Full Names: amyloid beta (A4) precursor protein-binding, family B, member 2
• NCBI Official Symbol: APBB2
• NCBI Official Synonym Symbols: FE65L; FE65L1
• NCBI Protein Information: amyloid beta A4 precursor protein-binding family B member 2; Fe65-like 1; protein Fe65-like 1
• UniProt Protein Name: Amyloid beta A4 precursor protein-binding family B member 2
• Protein Family: Amyloid beta A4 precursor protein-binding family
• UniProt Gene Name: APBB2
• UniProt Synonym Gene Names: FE65L; FE65L1
• UniProt Entry Name: APBB2_HUMAN

NCBI Description

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Uniprot Description

APBB2: May modulate the internalization of beta-amyloid precursor protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 4p13

Cellular Component: growth cone; membrane; lamellipodium; cytoplasm; synapse; nucleus

Molecular Function: protein binding; beta-amyloid binding; transcription factor binding

Biological Process: axon guidance; extracellular matrix organization and biogenesis; regulation of transcription, DNA-dependent; positive regulation of apoptosis; neuron migration; negative regulation of cell growth; cell cycle arrest; negative regulation of apoptosis

Disease: Alzheimer Disease