Mouse anti-Human Protein Phosphatase 2A, B56 gamma Monoclonal Antibody | anti-Ppp2r5c antibody

Protein Phosphatase 2A, B56 gamma (PP2g)

Cat. Num. AAA601308

• Gene Names: Ppp2r5c; C85228; AI060890; AW545884; mKIAA0044; D12Bwg0916e; 2610043M05Rik; 2700063L20Rik
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: Protein Phosphatase 2A; B56 gamma; Monoclonal Antibody; B56 gamma (PP2g); Anti -Protein Phosphatase 2A; anti-Ppp2r5c antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 7C5
• Specificity: Specific for the gamma isoform of the human B (or B56) regulatory subunit of protein phosphatase 2A (PP2A).
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

• Applicable Applications for anti-Ppp2r5c antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1-3ug/ml. Detects a band of ~60kD in human PP2A B56 -transfected 293T cell lysates.; Optimal working dilutions to be determined by researcher.
• Immunogen: Full-length human PP2A B56 gamma fusion protein, which is 90% homologous with mouse and rat.
• Positive Control: PP2A B56gamma-transfected 293T cell lysates.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-Ppp2r5c antibody

Protein phosphatase type 2A (PP2A) is a major eukaryotic serine/threonine protein phosphatase (PPase). PP2A is highly conserved and often exist as a heterotrimeric enzyme composed of a catalytic (C) subunit, a structural (A) subunit, and a variable regulatory/targeting (B-type) subunit1. Recent studies show that PP2A plays important roles in cell cycle regulation,signal transduction, cell differentiation, and transformation1-3. Its activity is also related to several diseases, including neurodegenerative diseases and cancer. The enzymatic activity and intracellular localization of PP2A are determined by three distinct families of cellular regulatory

Product Categories/Family for anti-Ppp2r5c antibody

Antibodies; Abs to Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 12862390
• NCBI GeneID: 26931
• UniProt Accession #: Q3TSR8; Q60996; Q6ZQK4; Q8C8H4
• Molecular Weight: 11,045 Da
• NCBI Official Full Name: protein phosphatase 2A B56 regulatory subunit gamma 2 isoform
• NCBI Official Synonym Full Names: protein phosphatase 2, regulatory subunit B (B56), gamma isoform
• NCBI Official Symbol: Ppp2r5c
• NCBI Official Synonym Symbols: C85228; AI060890; AW545884; mKIAA0044; D12Bwg0916e; 2610043M05Rik; 2700063L20Rik
• NCBI Protein Information: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; Band 8A; B56/PP2A gamma; PP2A B subunit isoform B'-gamma; PP2A B subunit isoform R5-gamma; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform B'-alpha-3; PP2A B subunit isoform PR61-gamma
• UniProt Protein Name: Putative uncharacterized protein
• Protein Family: Serine/threonine-protein phosphatase
• UniProt Gene Name: Ppp2r5c
• UniProt Entry Name: Q3TSR8_MOUSE

Uniprot Description

PPP2R5C: a regulatory subunit of PP2A that might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.Three alternatively spliced human isoforms have been described.

Protein type: Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis

Cellular Component: protein phosphatase type 2A complex; chromosome; nucleus; chromosome, pericentric region

Molecular Function: protein binding; protein phosphatase type 2A regulator activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; signal transduction