Testing Data
Mouse anti-Human Catenin, delta 1 Monoclonal Antibody | anti-CTNND1 antibody
Catenin, delta 1 (CTNND1, Cadherin-Associated Protein delta 1, Cadherin-associated Src Substrate, CAS, p120 Catenin, p120(ctn), p120(cas), KIAA0384)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Dilution: Flow Cytometry: 0.5-2ug/ml
Western Blot: 0.5-2ug/ml
Immunocytochemistry: 2-50ug/ml
Testing Data
Testing Data
Western Blot (WB)
(Detection of human CTNND1 by Western blot. Samples: Whole cell lysate (25 μg) from HeLa cells. Predicted molecular weight: 104 kD)
Western Blot (WB)
(Detection of human CTNND1 by Western blot. Samples: Whole cell lysate (25 μg) from HeLa cells. Predicted molecular weight: 104 kD)
Immunoprecipitation (IP)
(Immunoprecipitation: RIPA lysate of HeLa cells was incubated with MBS601249)
Immunoprecipitation (IP)
(Immunoprecipitation: RIPA lysate of HeLa cells was incubated with MBS601249)
Testing Data
(HeLa cells were fixed in 2% paraformaldehyde/PBS and then permeabilized in 90% methanol. Cells were stained with MBS601249(shaded) or isotype control (unshaded) followed by Alexa Fluor® 488- conjugated goat anti-mouse IgG.)
Testing Data
(HeLa cells were fixed in 2% paraformaldehyde/PBS and then permeabilized in 90% methanol. Cells were stained with MBS601249(shaded) or isotype control (unshaded) followed by Alexa Fluor® 488- conjugated goat anti-mouse IgG.)
Immunostaining (IS)
(Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with MBS601249)
Immunostaining (IS)
(Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with MBS601249)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq]
Uniprot Description
CTNND1: an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. A downstream modulator of Wnt/beta-catenin signaling pathway whose stability may be regulated downstream of Dsh. Required for the invasiveness of E-cadherin-deficient cells. A signal coordinator between cadherins and Rho-family GTPases to regulate cytoskeletal changes required during dendritic spine and synapse development. The association of catenins with cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Thirty two splice-variant isoforms have been described.
Protein type: Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; G protein regulator, misc.; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11q11
Cellular Component: growth cone; lamellipodium; cytoplasm; plasma membrane; dendritic spine; synapse; midbody; zonula adherens; intercellular junction; nucleus; cytosol
Molecular Function: protein binding; cadherin binding; protein kinase binding; receptor binding
Biological Process: intercellular junction assembly and maintenance; cell-cell adhesion; Wnt receptor signaling pathway; transcription, DNA-dependent; regulation of transcription, DNA-dependent; brain development; vascular endothelial growth factor receptor signaling pathway; cell adhesion
Research Articles on CTNND1
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Product Notes
The CTNND1 (Catalog #AAA601249) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Catenin, delta 1 (CTNND1, Cadherin-Associated Protein delta 1, Cadherin-associated Src Substrate, CAS, p120 Catenin, p120(ctn), p120(cas), KIAA0384) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Catenin, delta 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS). Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Immunocytochemistry. Dilution: Flow Cytometry: 0.5-2ug/ml Western Blot: 0.5-2ug/ml Immunocytochemistry: 2-50ug/ml. Researchers should empirically determine the suitability of the CTNND1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Catenin, delta 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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