Rabbit anti-Human, Mouse HSPA1L Polyclonal Antibody | anti-HSPA1L antibody

HSPA1L (Heat Shock 70kD Protein 1-like, HSP70-Hom, Heat shock 70kD protein 1L, Heat Shock 70kD Protein 1-Hom)

Cat. Num. AAA6011964

• Gene Names: HSPA1L; HSP70T; hum70t; HSP70-1L; HSP70-HOM
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: HSPA1L; Polyclonal Antibody; HSPA1L (Heat Shock 70kD Protein 1-like; HSP70-Hom; Heat shock 70kD protein 1L; Heat Shock 70kD Protein 1-Hom); Anti -HSPA1L (Heat Shock 70kD Protein 1-like; anti-HSPA1L antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human HSPA1L. Species Crossreactivity: mouse.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MATAKGIAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDAKRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLTKLKETAEAFLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGERHVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKMDKAKIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLLDVAPLSLGLETAGGVMTALMKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKVNKITIANDKGRLSKEEIERMVLDAEKYKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISESDKNKILDKCNELLSWLEVNQLAEKDEFDHKRKELEQMCNPIITKLYQGGCTGPACGTGYVPGRPATGPTIEEVD

• Applicable Applications for anti-HSPA1L antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human HSPA1L, aa1-641 (AAH34483.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(HSPA1L rabbit polyclonal antibody. Western Blot analysis of HSPA1L expression in mouse testis.)

Western Blot (WB)

(Western Blot analysis of HSPA1L expression in transfected 293T cell line by HSPA1L polyclonal antibody. Lane 1: HSPA1L transfected lysate (70.4kD). Lane 2: Non-transfected lysate)

Testing Data

(Proximity Ligation Analysis (PLA) of protein-protein interactions between HSPA1L and TP53 HeLa cells were stained with HSPA1L rabbit purified polyclonal 1:1200 and TP53 mouse monoclonal antibody 1:50. Signals were detected 30 Detection Kit 613 (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.)

Related Product Information for anti-HSPA1L antibody

HSPA1L is a 70kD heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles.

Product Categories/Family for anti-HSPA1L antibody

Antibodies; Abs to Heat Shock Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 124256496
• NCBI GeneID: 3305
• NCBI Accession #: NP_005518.3
• NCBI GenBank Nucleotide #: NM_005527.3
• UniProt Accession #: P34931; O75634; Q2HXR3; Q8NE72; Q96QC9; Q9UQM1; A6NNB0; B0UXW8
• Molecular Weight: 70,375 Da
• NCBI Official Full Name: heat shock 70 kDa protein 1-like
• NCBI Official Synonym Full Names: heat shock 70kDa protein 1-like
• NCBI Official Symbol: HSPA1L
• NCBI Official Synonym Symbols: HSP70T; hum70t; HSP70-1L; HSP70-HOM
• NCBI Protein Information: heat shock 70 kDa protein 1-like; heat shock 70 kDa protein 1L; heat shock 70kD protein-like 1; heat shock 10kDa protein 1-like; heat shock 70 kDa protein 1-Hom
• UniProt Protein Name: Heat shock 70 kDa protein 1-like
• Protein Family: Heat shock 70 kDa protein
• UniProt Gene Name: HSPA1L
• UniProt Synonym Gene Names: Heat shock 70 kDa protein 1L; HSP70-Hom
• UniProt Entry Name: HS71L_HUMAN

NCBI Description

This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]

Uniprot Description

HSPA1L: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Not induced by heat shock. Expressed in spermatids. Belongs to the heat shock protein 70 family.

Protein type: Mitochondrial; Chaperone; Heat shock protein

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: signalosome; nucleoplasm; mitochondrial matrix; cytosol

Molecular Function: protein binding; unfolded protein binding; ATP binding

Biological Process: binding of sperm to zona pellucida; protein refolding; response to unfolded protein