Rabbit anti-Human, Rat Latexin Polyclonal Antibody | anti-LXN antibody

Latexin (Endogenous Carboxypeptidase Inhibitor, ECI, Protein MUM, Tissue Carboxypeptidase Inhibitor, TCI, LXN)

Cat. Num. AAA6011870

• Gene Names: LXN; ECI; TCI
• Reactivity: Human, Rat
• Applications: Immunohistochemistry
• Purity: Serum; Serum
• Synonyms: Latexin; Polyclonal Antibody; Latexin (Endogenous Carboxypeptidase Inhibitor; ECI; Protein MUM; Tissue Carboxypeptidase Inhibitor; TCI; LXN); Anti -Latexin (Endogenous Carboxypeptidase Inhibitor; anti-LXN antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Latexin. Species Crossreactivity
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.

• Applicable Applications for anti-LXN antibody: Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry.; Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 1:100
• Immunogen: Synthetic peptide corresponding to aa70-86 (CTAEVLYPSTGQETAPE) of human Latexin.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Immunohistochemical analysis of Latexin in paraffin-embedded formalin-fixed rat brain tissue using an isotype control (top, left) and MBS6011870 (bottom, left and right (100X)) at 1:100.)

Related Product Information for anti-LXN antibody

Latexin, or tissue carboxypeptidase inhibitor (TCI), is the only known mammalian carboxypeptidase inhibitor. It is often related to a human putative tumor suppressor protein, TIG1. Latexin was first identified as a marker of neurons in the lateral neocortex of the developing mammalian brain. Latexin plays a role in the modulation of sensory perception and also functions in inflammation and innate immune pathways. The protein also contributes to the pathological disorders acute pancreatitis and lung inflammation. Latexin is expressed in heart, prostate, ovary, kidney, pancreas, colon and brain. The human latexin gene is assigned to chromosomal region 3q25.32.

Product Categories/Family for anti-LXN antibody

Antibodies; Abs to Protease Inhibitors

NCBI and Uniprot Product Information

• NCBI GI #: 194473714
• NCBI GeneID: 56925
• NCBI Accession #: NP_064554.3
• NCBI GenBank Nucleotide #: NM_020169.3
• UniProt Accession #: Q9BS40; Q96PN2; Q9NQS6
• Molecular Weight: 25,750 Da
• NCBI Official Full Name: latexin
• NCBI Official Synonym Full Names: latexin
• NCBI Official Symbol: LXN
• NCBI Official Synonym Symbols: ECI; TCI
• NCBI Protein Information: latexin; MUM; tissue carboxypeptidase inhibitor; endogenous carboxypeptidase inhibitor
• UniProt Protein Name: Latexin
• Protein Family: Latexin
• UniProt Gene Name: LXN
• UniProt Synonym Gene Names: ECI; TCI
• UniProt Entry Name: LXN_HUMAN

NCBI Description

This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008]

Uniprot Description

LXN: Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. Belongs to the protease inhibitor I47 (latexin) family.

Chromosomal Location of Human Ortholog: 3q25.32

Cellular Component: cytoplasm

Molecular Function: metalloendopeptidase inhibitor activity; heparin binding

Biological Process: inflammatory response; detection of temperature stimulus involved in sensory perception of pain