Rabbit anti-Human, Mouse MLL-C Polyclonal Antibody
MLL-C (Histone-lysine N-methyltransferase MLL, ALL-1, CXXC-type Zinc Finger Protein 7, Lysine N-methyltransferase 2A, KMT2A, Trithorax-like Protein, Zinc Finger Protein HRX, MLL Cleavage Product C180, C-terminal Cleavage Product of 180kD, p180, MLL, ALL1,
Reactivity
Human, Mouse
Applications
Western Blot, Immunocytochemistry
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
MLL-C; Polyclonal Antibody; MLL-C (Histone-lysine N-methyltransferase MLL; ALL-1; CXXC-type Zinc Finger Protein 7; Lysine N-methyltransferase 2A; KMT2A; Trithorax-like Protein; Zinc Finger Protein HRX; MLL Cleavage Product C180; C-terminal Cleavage Product of 180kD; p180; MLL; ALL1; ; Anti -MLL-C (Histone-lysine N-methyltransferase MLL; anti-MLL-C antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Specificity
Recognizes human MLL-C. Species Crossreactivity: Mouse.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Applicable Applications for anti-MLL-C antibody
Western Blot (WB), Immunocytochemistry (ICC)
Application Notes
Suitable for use in Western Blot and Immunocytochemistry.
Dilution: Western Blot: 1:1000
Immunocytochemistry: 1:500
Dilution: Western Blot: 1:1000
Immunocytochemistry: 1:500
Immunogen
Recombinant corresponding to human MLL-C fused to GST-tag.
Positive Control
HeLa nuclear extract
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-MLL-C antibody
MLL is a histone methyltransferase and chromatin modifier that plays a role in hematopoiesis. This protein is implicated in HOX gene regulation in early embryogenesis and in the regulation of non-HOX genes p27 (Kip1) and p18 (lnk4C). It is part of a catalytic subunit of the MLL1/MLL complex, which mediates the acetylation of aa16 of histone H4 (H4K16ac) and the methylation of aa4 of histone H3 (H3K4me). It is reported that MLL interacts directly with the polymerase associated factor complex (PAFc) through sequences flanking the CxxC domain. Subsequently, PAFc interacts with RNA polymerase II and thereby stimulates posttranslational histone modifications. Taspase 1, catalyzes MLL into MLL-C and MLL-N, both of which reassociate and later reassemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Mutations in the MLL gene are linked to certain acute myeloid and lymphoid leukemias.
Product Categories/Family for anti-MLL-C antibody
Similar Products
Product Notes
The MLL-C (Catalog #AAA6010678) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MLL-C (Histone-lysine N-methyltransferase MLL, ALL-1, CXXC-type Zinc Finger Protein 7, Lysine N-methyltransferase 2A, KMT2A, Trithorax-like Protein, Zinc Finger Protein HRX, MLL Cleavage Product C180, C-terminal Cleavage Product of 180kD, p180, MLL, ALL1, reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's MLL-C can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC). Suitable for use in Western Blot and Immunocytochemistry. Dilution: Western Blot: 1:1000 Immunocytochemistry: 1:500. Researchers should empirically determine the suitability of the MLL-C for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MLL-C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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