Mouse anti-Rat CACNA1D Monoclonal Antibody | anti-cacna1da antibody

CACNA1D (Voltage-dependent L-type Calcium Channel Subunit alpha-1D, Calcium Channel, L Type, alpha-1 Polypeptide, Isoform 2, Rat Brain Class D, RBD, Voltage-gated Calcium Channel Subunit alpha Cav1.3, Cach3, Cacn4, Cacnl1a2, Cchl1a2)

Cat. Num. AAA6010178

• Gene Names: cacna1da; isl; cacna1d; cav1.3a; si:dz223c6.1; si:dz136d19.3
• Reactivity: Rat
• Applications: Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: CACNA1D; Monoclonal Antibody; CACNA1D (Voltage-dependent L-type Calcium Channel Subunit alpha-1D; Calcium Channel; L Type; alpha-1 Polypeptide; Isoform 2; Rat Brain Class D; RBD; Voltage-gated Calcium Channel Subunit alpha Cav1.3; Cach3; Cacn4; Cacnl1a2; Cchl1a2); Anti -CACNA1D (Voltage-dependent L-type Calcium Channel Subunit alpha-1D; anti-cacna1da antibody

• Host: Mouse
• Reactivity: Rat
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: S48A-9
• Specificity: Recognizes rat CACNA1D at ~250kD. Does not react with Cav1.2. Species sequence homology: human and mouse.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4.

• Applicable Applications for anti-cacna1da antibody: Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in Western Blot, Immunocytochemistry, Immunoprecipitation and Immunohistochemistry.; Dilution: Western Blot: 1-10ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml; Immunocytochemistry: 0.1-1ug/ml; Immunoprecipitation: 1-10ug/ml
• Immunogen: Fusion protein corresponding to aa859-875 from rat Cav1.3.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Rat Brain: Formalin-Fixed, Paraffin-Embedded (FFPE))

Testing Data

(Cav1.3 (S48A-9), Human cell line mix.)

Testing Data

(Cav1.3 (S48A-9), Human hippocampus.)

Testing Data

(Cav1.3 (S48A-9), Mouse back skin(2).)

Testing Data

(Cav1.3 (S48A-9), Mouse back skin.)

Related Product Information for anti-cacna1da antibody

Cacna1d is the neuroendocrine alpha Cav1 subunit of the voltage-gated calcium channel. In mice, it has been suggested that Cacna1d participates in auditory function and cardiac pacemaker activity. At least two isoforms of this gene have been identified.

Product Categories/Family for anti-cacna1da antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 190337315
• NCBI GeneID: 403310
• NCBI Official Full Name: Cacna1d protein
• NCBI Official Synonym Full Names: calcium channel, voltage-dependent, L type, alpha 1D subunit, a
• NCBI Official Symbol: cacna1da
• NCBI Official Synonym Symbols: isl; cacna1d; cav1.3a; si:dz223c6.1; si:dz136d19.3
• NCBI Protein Information: voltage-dependent L-type calcium channel subunit alpha-1D; gem; gemini; L-type calcium channel pore subunit isoform 1.3a

Uniprot Description

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.