Western Blot (WB)
(Anti-CaV1.3 antibody, MBS176827, All Western blottingAll lanes: Anti-CACNA1D(MBS176827) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 40ugPredicted bind size: 245KDObserved bind size: 245KD)
Rabbit CaV1.3 Polyclonal Antibody | anti-CACNA1D antibody
Anti-CaV1.3 antibody
Western Blot (WB)
(Anti-CaV1.3 antibody, MBS176827, All Western blottingAll lanes: Anti-CACNA1D(MBS176827) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 40ugPredicted bind size: 245KDObserved bind size: 245KD)
Western Blot (WB)
(Anti-CaV1.3 antibody, MBS176827, All Western blottingAll lanes: Anti-CACNA1D(MBS176827) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 40ugPredicted bind size: 245KDObserved bind size: 245KD)
Background: Cav1.3, also known as the calcium channel, voltage-dependent, L type, alpha 1D subunit(CACNA1D), is a human gene. It is mapped to 3p21.1. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Alpha-1D subunit can mediate DHP-sensitive, high voltage-activated, long-lasting calcium channel activity. CACNA1D can form L-type calcium channels with negative activation thresholds which is essential for normal auditory function and controling of cardiac pacemaker activity.
NCBI and Uniprot Product Information
NCBI Description
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Uniprot Description
CACNA1D: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium
Chromosomal Location of Human Ortholog: 3p14.3
Cellular Component: plasma membrane; voltage-gated calcium channel complex; Z disc
Molecular Function: voltage-gated calcium channel activity; metal ion binding; high voltage-gated calcium channel activity; ankyrin binding; alpha-actinin binding
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; axon guidance; sensory perception of sound; calcium ion transport; energy reserve metabolic process; positive regulation of calcium ion transport; regulation of insulin secretion
Disease: Primary Aldosteronism, Seizures, And Neurologic Abnormalities; Sinoatrial Node Dysfunction And Deafness
Research Articles on CACNA1D
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Product Notes
The CACNA1D cacna1d (Catalog #AAA176827) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CaV1.3 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CaV1.3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CACNA1D cacna1d for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CaV1.3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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