Rabbit anti-Human CRYGD Polyclonal Antibody | anti-Crygd antibody

CRYGD (Gamma-crystallin D, Gamma-D-crystallin, Gamma-crystallin 4, CRYG4)

Cat. Num. AAA6008472

• Gene Names: Crygd; Aey4; Lop12; Cryg-1; DGcry-1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: CRYGD; Polyclonal Antibody; CRYGD (Gamma-crystallin D; Gamma-D-crystallin; Gamma-crystallin 4; CRYG4); Anti -CRYGD (Gamma-crystallin D; anti-Crygd antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CRYGD.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRRGDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS

• Applicable Applications for anti-Crygd antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human CRYGD, aa1-174 (NP_008822.2).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of CRYGD expression in transfected 293T cell line by CRYGD polyclonal antibody. Lane 1: CRYGD transfected lysate (20.7kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-Crygd antibody

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.

Product Categories/Family for anti-Crygd antibody

Antibodies; Abs to Crystallins

NCBI and Uniprot Product Information

• NCBI GI #: 34784220
• NCBI GeneID: 12967
• UniProt Accession #: P04342; O89027; Q6PGI0
• Molecular Weight: 21,118 Da
• NCBI Official Full Name: Crygd protein
• NCBI Official Synonym Full Names: crystallin, gamma D
• NCBI Official Symbol: Crygd
• NCBI Official Synonym Symbols: Aey4; Lop12; Cryg-1; DGcry-1
• NCBI Protein Information: gamma-crystallin D; lens opacity 12; gamma-D-crystallin; gamma-crystallin 1
• UniProt Protein Name: Gamma-crystallin D
• Protein Family: Gamma-crystallin
• UniProt Gene Name: Crygd
• UniProt Entry Name: CRGD_MOUSE

Uniprot Description

CRYGD: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family. Defects are the cause of congenital zonular cataract with sutural opacities. Two splice-variant isoforms have been described.

Protein type: Cytoskeletal

Cellular Component: cytoplasm; nucleus

Molecular Function: structural constituent of eye lens

Biological Process: lens development in camera-type eye; visual perception; eye development