Western Blot (WB)
(Western Blot analysis of TAF1C expression in transfected 293T cell line by TAF1C polyclonal antibody. Lane 1: TAF1C transfected lysate (85.25kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human TAF1C Polyclonal Antibody | anti-TAF1C antibody
TAF1C (TATA Box-binding Protein-associated Factor RNA Polymerase I Subunit C, RNA Polymerase I-specific TBP-associated Factor 110 kDa, TAFI110, TATA Box-binding Protein-associated Factor 1C, TBP-associated Factor 1C, Transcription Initiation Factor SL1/TI
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of TAF1C expression in transfected 293T cell line by TAF1C polyclonal antibody. Lane 1: TAF1C transfected lysate (85.25kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of TAF1C expression in transfected 293T cell line by TAF1C polyclonal antibody. Lane 1: TAF1C transfected lysate (85.25kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]
Uniprot Description
TAF1C: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription initiation complex
Chromosomal Location of Human Ortholog: 16q24
Cellular Component: nucleoplasm
Molecular Function: protein binding; DNA binding
Biological Process: transcription from RNA polymerase II promoter; chromatin silencing at rDNA; negative regulation of gene expression, epigenetic; transcription from RNA polymerase I promoter; RNA elongation from RNA polymerase I promoter; gene expression; transcription initiation from RNA polymerase I promoter; termination of RNA polymerase I transcription; regulation of gene expression, epigenetic
Research Articles on TAF1C
Similar Products
Product Notes
The TAF1C taf1c (Catalog #AAA6006403) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TAF1C (TATA Box-binding Protein-associated Factor RNA Polymerase I Subunit C, RNA Polymerase I-specific TBP-associated Factor 110 kDa, TAFI110, TATA Box-binding Protein-associated Factor 1C, TBP-associated Factor 1C, Transcription Initiation Factor SL1/TI reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TAF1C can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the TAF1C taf1c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MLPPLIDPWD PGLTARDLLF RGGYRYRKRP RVVLDVTEQI SRFLLDHGDV AFAPLGKLML ENFKLEGAGS RTKKKTVVSV KKLLQDLGGH QPWGCPWAYL SNRQRRFSIL GGPILGTSVA SHLAELLHEE LVLRWEQLLL DEACTGGALA WVPGRTPQFG QLVYPAGGAQ DRLHFQEVVL TPGDNPQFLG KPGRIQLQGP VRQVVTCTVQ GETLLAVRSD YHCAVWKFGK QWQPTLLQAM QVEKGATGIS LSPHLPGELA ICSRSGAVCL WSPEDGLRQI YRDPETLVFR DSSSWRWADF TAHPRVLTVG DRTGVKMLDT QGPPGCGLLL FRLGAEASCQ KGERVLLTQY LGHSSPKCLP PTLHLVCTQF SLYLVDERLP LVPMLKWNHG LPSPLLLARL LPPPRPSCVQ PLLLGGQGGQ LQLLHLAEGA SVPRLAGPPQ SLPSRIDSLP AFPLLEPKIQ WRLQERLKAP TIGLAAVVPP MPSAPTPGLV LFQLSAAGDV FYQQLRPQVD SSLRRDAGPP GDTQPDCHAP TASWTSQDTA GCSQWLKALL KVPLAPPVWT APTFTHRQML GSTELRREEE EGQRLGVLRK AMARGQLLLQ RDLGSLPAAE PPPAPESGLE DKLSERLGEA WAGRGAAWWE RQQGRTSEPG RQTRRPKRRT QLSSSFSLSG HVDPSEDTSS PHSPEWPPAD ALPLPPTTPP SQELTPDACA QGVPSEQRQM LRDYMAKLPP QRDTPGCATT PPHSQASSVR ATRSQQHTPV LSSSQPLRKK PRMGF. It is sometimes possible for the material contained within the vial of "TAF1C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
