Rabbit anti-Human, Mouse GRPEL2 Polyclonal Antibody | anti-GRPEL2 antibody

GRPEL2, NT (GRPEL2, GrpE protein homolog 2, mitochondrial, Mt-GrpE#2)

Cat. Num. AAA6003898

• Gene Names: GRPEL2; Mt-GrpE#2
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: GRPEL2; Polyclonal Antibody; NT (GRPEL2; GrpE protein homolog 2; mitochondrial; Mt-GrpE#2); Anti -GRPEL2; anti-GRPEL2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human, mouse
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-GRPEL2 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: GRPEL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-43 amino acids from the N-terminal region of human GRPEL2.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(GRPEL2 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GRPEL2 antibody detected the GRPEL2 protein (arrow).)

Western Blot (WB)

(GRPEL2 Antibody (N-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the GRPEL2 antibody detected the GRPEL2 protein (arrow).)

Related Product Information for anti-GRPEL2 antibody

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity).

Product Categories/Family for anti-GRPEL2 antibody

Antibodies; Abs to Mitochondrial Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 40255109
• NCBI GeneID: 134266
• NCBI Accession #: NP_689620.2
• NCBI GenBank Nucleotide #: NM_152407.3
• UniProt Accession #: Q8TAA5; Q49AJ6
• Molecular Weight: 25,431 Da
• NCBI Official Full Name: grpE protein homolog 2, mitochondrial
• NCBI Official Synonym Full Names: GrpE-like 2, mitochondrial (E. coli)
• NCBI Official Symbol: GRPEL2
• NCBI Official Synonym Symbols: Mt-GrpE#2
• NCBI Protein Information: grpE protein homolog 2, mitochondrial
• UniProt Protein Name: GrpE protein homolog 2, mitochondrial
• Protein Family: GrpE protein
• UniProt Gene Name: GRPEL2
• UniProt Entry Name: GRPE2_HUMAN

Uniprot Description

GRPEL2: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70. Belongs to the GrpE family.

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane

Molecular Function: protein homodimerization activity; adenyl-nucleotide exchange factor activity; chaperone binding; unfolded protein binding

Biological Process: cellular protein metabolic process; protein folding; regulation of catalytic activity; protein targeting to mitochondrion