Mouse anti-Human IL-17A Monoclonal Antibody | anti-IL-17A antibody
Mouse monoclonal antibody to human IL-17A, Clone 2D11
Reactivity
Human
Purity
Protein G affinity purified
Synonyms
IL-17A; Monoclonal Antibody; Mouse monoclonal antibody to human IL-17A; Clone 2D11; mAb anti Human IL-17A clone 2D11; anti-IL-17A antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse, IgG1 Kappa
Clone Number
2D11
Specificity
Reactive with recombinant human IL-17A
Purity/Purification
Protein G affinity purified
Form/Format
Lyophilized from a solution in 0.01M PBS, pH 7.0
Immunogen
Purified, human cell expressed recombinant human IL-17A
Fusion Myeloma
SP2/0
Reconstitution
Double distilled water is recommended to reconstitute the antibody to 1mg/mL.
Neutralization
IL-17A antibody clone 2D11 inhibited IL-17A induced IL-6 expression in human dermal fibroblast. The IC50 was less than 0.25mg/ml.
Preparation and Storage
Store at -20 degree C
Related Product Information for anti-IL-17A antibody
IL-17A is an inflammatory cytokine produced by Th17 cells, a newly characterised group of CD4 T help cells that plays a role in autoimmune diseases and chronic inflammatory diseases. IL-23 is the main inducer of Th17 cell development. Other cytokines such as TGF-beta, IL-6 and IL-21 were also found to contribute to the procedure. IL-17A belongs to the IL-17 family which includes IL-17A, IL-17B, IL-17C, IL-17D and IL-17E. IL-17, like interferon-gamma, is a potent mediator of delayed-type reaction. IL-17 induces the secretion of many other pro-inflammatory cytokines and chemokines such as IL-6, IL-8, GM-CSF, G-CSF, TGF-beta, TNF-alpha, GRO-alpha, and MCP-1. IL-17 stimulates the expression of NF-kappaB, mitogen activated protein kinase, and prostaglandings by many cell types, and enhances the production of nitric oxide.
Product Categories/Family for anti-IL-17A antibody
Uniprot Description
Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus.
Subunit structure: Homodimer.
Subcellular location: Secreted.
Tissue specificity: Alveolar macrophages.
Induction: By lipopolysaccharide (LPS).
Post-translational modification: Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation
By similarity.
Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.
Research Articles on IL-17A
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Product Notes
The IL-17A (Catalog #AAA592456) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse monoclonal antibody to human IL-17A, Clone 2D11 reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "IL-17A, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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