Mouse anti-Human Programmed Cell Death-1 Monoclonal Antibody | anti-PD-1 antibody
mAb anti-Human Programmed Cell Death-1
Reactivity
Human
Applications
ELISA, Immunohistochemistry
Purity
Protein G Affinity Purified
Synonyms
Programmed Cell Death-1; Monoclonal Antibody; mAb anti-Human Programmed Cell Death-1; Human Programmed Cell Death-1 (PD-1) / CD279; anti-PD-1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
B1C4
Specificity
The mAb is reactive with human programmed cell death-1 (PD-1).
Purity/Purification
Protein G Affinity Purified
Form/Format
Lyophilized from a solution in 0.01M PBS, pH 7.2
Applicable Applications for anti-PD-1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
Indirect ELISA: The antibody is reactive to recombinant human programmed cell death-1 (PD-1).
IHC: This antibody reacts with thymus gland section.
The thymus gland tissue section below was treated by heat induced epitope retrieval before primary antibody (20ug/mL) was added. The secondary antibody was an HRP-labelled goat anti-mouse IgG antibody.
IHC: This antibody reacts with thymus gland section.
The thymus gland tissue section below was treated by heat induced epitope retrieval before primary antibody (20ug/mL) was added. The secondary antibody was an HRP-labelled goat anti-mouse IgG antibody.
Research Area
Immunosuppression
Fusion Myeloma
Sp2/0-Ag14
Immunogen
40kDa recombinant human programmed cell death-1 (PD-1)
Target Protein
Human programmed cell death-1 (PD-1).
Preparation and Storage
Store at -20 degree C
Related Product Information for anti-PD-1 antibody
Description: Mouse monoclonal antibody (mAb) to human programmed cell death-1 (PD-1), or mouse mAb to human CD279.
Background: Programmed Cell Death-1 (PD-1), also called CD279, is a 288 amino acid cell surface protein that belongs to the immunoglobulin superfamily. The protein is expressed on T cells, B cells and macrophages. When PD-1 is joined with its ligand (CD274 or B7-H1), the immune cell's activation and effector function are attenuated. Research suggested that PD1 pathway is mainly involved with attenuation at periphery sites while the B7/CTLA-4 pathway is primarily involved with the attenuation of the activation of immune cells in secondary lymphoid organs. PD-1 pathway is implicated with cancer's immune-evasion, autoimmunity, and Listeria monocytogenes infection.
Background: Programmed Cell Death-1 (PD-1), also called CD279, is a 288 amino acid cell surface protein that belongs to the immunoglobulin superfamily. The protein is expressed on T cells, B cells and macrophages. When PD-1 is joined with its ligand (CD274 or B7-H1), the immune cell's activation and effector function are attenuated. Research suggested that PD1 pathway is mainly involved with attenuation at periphery sites while the B7/CTLA-4 pathway is primarily involved with the attenuation of the activation of immune cells in secondary lymphoid organs. PD-1 pathway is implicated with cancer's immune-evasion, autoimmunity, and Listeria monocytogenes infection.
Product Categories/Family for anti-PD-1 antibody
NCBI and Uniprot Product Information
NCBI GI #
Similar Products
Product Notes
The PD-1 (Catalog #AAA592422) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The mAb anti-Human Programmed Cell Death-1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Programmed Cell Death-1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Indirect ELISA: The antibody is reactive to recombinant human programmed cell death-1 (PD-1). IHC: This antibody reacts with thymus gland section. The thymus gland tissue section below was treated by heat induced epitope retrieval before primary antibody (20ug/mL) was added. The secondary antibody was an HRP-labelled goat anti-mouse IgG antibody. Researchers should empirically determine the suitability of the PD-1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Programmed Cell Death-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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