Rabbit anti-Rat Low Density Lipoprotein Receptor LDLR Polyclonal Antibody | anti-LDLR antibody
Low Density Lipoprotein Receptor LDLR Rabbit Polyclonal Antibody
Reactivity
Rat
Applications
Western Blot
Synonyms
Low Density Lipoprotein Receptor LDLR; Polyclonal Antibody; Low Density Lipoprotein Receptor LDLR Rabbit Polyclonal Antibody; QLDL receptor; anti-LDLR antibody
Host
Rabbit
Reactivity
Rat
Clonality
Polyclonal
Specificity
Specifically recognizes the LDL receptor at a molecular weight of 160 kDa. The antibody recognizes the C-terminal portion of LDLR.
Form/Format
Lyophilized Serum
Applicable Applications for anti-LDLR antibody
Western Blot (WB)
Application Notes
If reconstituted in 100 muL: WB: 1:1500.
Immunogen
C-terminal peptide
Preservative
None
Preparation and Storage
Lyophilized antibody can be kept at 4 degree C for up to 3 months and should be kept at-20 degree C for long-term storage.
To avoid freeze-thaw cycles, reconstituted antibody should be aliquoted before freezing for short-term storage (-20 degree C) or for long-term storage (-80 degree C).
For maximum recovery of product centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
To avoid freeze-thaw cycles, reconstituted antibody should be aliquoted before freezing for short-term storage (-20 degree C) or for long-term storage (-80 degree C).
For maximum recovery of product centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-LDLR antibody
The LDL Receptor (LDLR) is a transmembrane protein of 839 amino acids that mediates the endocytosis of cholesterol-rich LDL. The LDL receptor plays a critical role in cholesterol homeostasis. It binds, internalizes, and removes LDL from serum. LDLR recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles, as well as the apoE protein found in chylomicron remnants and VLDL remnants (IDL). To be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits (or buds) on the cell surface. Defects in LDLR are the cause of familial hypercholesterolemia, a common autosomal semi-dominant disease that affects about 1 in 500 individuals.
References
1. Ibrahim S-Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol.
NCBI and Uniprot Product Information
NCBI GI #
Protein Family
Similar Products
Product Notes
The LDLR (Catalog #AAA588288) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Low Density Lipoprotein Receptor LDLR Rabbit Polyclonal Antibody reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Low Density Lipoprotein Receptor LDLR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). If reconstituted in 100 muL: WB: 1:1500. Researchers should empirically determine the suitability of the LDLR for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Low Density Lipoprotein Receptor LDLR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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