Rabbit anti-Human Tau Cleaved By Caspase-6 Polyclonal Antibody | anti-TAU antibody

Tau Cleaved By Caspase-6 Rabbit Polyclonal Antibody

Cat. Num. AAA588231

• Reactivity: Human
• Applications: Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
• Synonyms: Tau Cleaved By Caspase-6; Polyclonal Antibody; Tau Cleaved By Caspase-6 Rabbit Polyclonal Antibody; Microtubule-associated protein tau. Neurofibrillary tangle protein; Paired helical filament-tau; MAPT; MAPTL; MTBT1; anti-TAU antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody recognizes the sequence (KSPVVSGD) in the human tau protein. It is expected that other species displaying the same amino acid in the tau protein will be recognized by the antibody
• Form/Format: Lyophilized serum

• Applicable Applications for anti-TAU antibody: Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: If reconstituted in 50 muL: WB: 1:100-1:500; IP: 1:100-1:500; IHC: 1:2000-1:10000.
• Preservative: None
• Preparation and Storage: Lyophilized antibody can be kept at 4 degree C for up to 3 months and should be kept at-20 degree C for long-term storage.; To avoid freeze-thaw cycles, reconstituted antibody should be aliquoted before freezing for short-term storage (-20 degree C) or for long-term storage (-80 degree C).; For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-TAU antibody

The tau protein is a microtubule-associated protein mainly expressed in neurons, which plays a crucial role in the neuronal cytoskeleton stabilization. The main role of tau proteins is to stabilize microtubules.Tau proteins are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in astrocytes and oligodendrocytes. Defects in tau proteins can result in dementias, such as Alzheimer's disease (AD). AD is a neurodegenerative pathology which is characterized by the presence of two types of neuropathological hallmarks: neurofibrillary tangles (NFTs) and senile plaques. NFTs are intraneuronal aggregations mainly composed of abnormally phosphorylated Tau. In neuropil threads (NPTs), NFTs, and neuritic plaques (NPs) of severe AD brains, highly abundant amounts of active caspase-6 and tau cleaved by caspase-6 (TauACsp6) have been found. Caspases are a family of cytosolic aspartate-specific cysteine proteases. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspase-6 has been associated with increasing (3-amyloid peptide in primary cultures of human neurons. Caspase-6 has also been demonstrated to be active in NPTs, NFTs, and NPs in the hippocampus and temporal cortex in sporadic AD. Caspase-6 activation has been suggested to be an early event in AD and to precede the development of lesions.

References

1. Albrecht S-Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations. 2. Albrecht S-Activation of caspase-6 in aging and mild cognitive impairment. 3. Guo H-Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease.