Related Product Information for anti-Tau antibody
Tauopathies are a group of diverse dementias and movement disorders which have a common pathological feature in that they all display the presence of intracellular accumulation of abnormal filaments of Tau protein. While the abnormal phosphorylation of Tau on serine and threonine has been well established in the disease process, its phosphorylation on tyrosine 18 has only recently been described as present in Alzheimer's disease (AD) brain.
References
1. Schweig JE-Alzheimer's disease pathological lesions activate the spleen tyrosine kinase. 2. Liu W-miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer's disease. 3. Dourlen P-Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. 4. Bhaskar K-Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy. 5. Lee G-Phosphorylation of tau by fyn: implications for Alzheimer's disease.
Product Notes
The Tau (Catalog #
AAA588135) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Phospho-Tau (tyr 18) Mouse Monoclonal Antibody (9G3) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Tau can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). If reconstituted in 100 muL: WB: 1:1000-1:5000; IHC: 1:1000-1:5000; IF: 1:2000-1:5000. Researchers should empirically determine the suitability of the Tau for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"Tau, Monoclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
any time and without notice. It is the responsibility of the customer to inform AAA Biotech
of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
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