Chemical Structure
KPT9274, inhibitor
KPT9274
Purity
0.9993
Synonyms
KPT9274; KPT 9274; KPT-9274; PAK4-IN-1; KPT-9274 KPT 9274; inhibitor
Purity/Purification
0.9993
Form/Format
Solid
Solubility
DMSO: 32mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
SMILES
FC1(F)CCN(CC1)C(=O)c2ccc(cc2)c4cc6cc(CNC(=O)/C=C/c3ccc(N)nc3)oc6c(c4)c5ccc(F)cc5
Formula
C35H29F3N4O3
Target & IC50
NAMPT, PAK4
Cell Research
786-0, ACHN, Caki-1 and U-2 OS cells are treated with KPT-9274 (1uM and 5uM) incubating for 12 hours.
In vitro
In mice, KPT-9274 (200 mg/kg) daily is administered either intravenously or orally with the absence of any signs of toxicity.
CAS Number
1643913-93-2
Preparation and Storage
Store at 0-4 degree C for short term (days to weeks), or -20 degree C for long term (months).
Chemical Structure
Chemical Structure
Related Product Information for KPT9274, inhibitor
KPT-9274 is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120). It is an orally bioavailable small molecule.
Product Categories/Family for KPT9274, inhibitor
References
Abu Aboud O,etal.Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth.Mol Cancer Ther. 2016 Sep;15(9):2119-29.
WO2015003166A1
WO2015003166A1
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Product Notes
The KPT9274 (Catalog #AAA5764886) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "KPT9274, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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