Adalimumab, Inhibitor
Adalimumab
Purity
99.9%
Synonyms
Adalimumab; Adalimumab (anti-TNF-alpha); anti-TNF-alpha; LU200134; D2E7; inhibitor
Purity/Purification
99.9%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
CAS Number
331731-18-1
Target & IC50
TNF-alpha
Cell Research
Objective: Adalimumab induces apoptosis of THP-1 cells Concentrations: 10ug/mL. Incubation Time: 6, 12, 18, 24, 30 hours Method: THP-1 cells (0.5x106) were incubated with anti-FcRI mAb and anti-FcRII mAb, and then cultured with adalimumab, infliximab, huIgG or vehicle (PBS) alone as indicated. LPS (1ug/mL) was added in all culture conditions. Apoptosis was analyzed at different time points by staining with annexin V-FITC and propidium iodide, Apo2.7-PE-conjugated antibody, or 7AAD. Cell lines: THP-1 cells
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Adalimumab, inhibitor
Adalimumab anti-TNF-alpha) is the first fully human recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha.
References
Mease PJ, et al. Adalimumab: an anti-TNF agent for the treatment,of psoriatic arthritis. Expert Opin Biol Ther. 2005 Nov;5(11):1491-504.
Mease PJ, et al. Adalimumab: an anti-TNF agent for the treatment,of psoriatic arthritis. Expert Opin Biol Ther. 2005 Nov;5(11):1491-504.
Elsakkar MG, et al. Adalimumab ameliorates OVA-induced airway inflammation in mice: Role of CD4(+) CD25(+) FOXP3(+) regulatory T-cells. Eur J Pharmacol. 2016 Sep 5;786:100-108.
Elsakkar MG, et al. Adalimumab ameliorates OVA-induced airway inflammation in mice: Role of CD4(+) CD25(+) FOXP3(+) regulatory T-cells. Eur J Pharmacol. 2016 Sep 5;786:100-108.
Mease PJ, et al. Adalimumab: an anti-TNF agent for the treatment,of psoriatic arthritis. Expert Opin Biol Ther. 2005 Nov;5(11):1491-504.
Elsakkar MG, et al. Adalimumab ameliorates OVA-induced airway inflammation in mice: Role of CD4(+) CD25(+) FOXP3(+) regulatory T-cells. Eur J Pharmacol. 2016 Sep 5;786:100-108.
Elsakkar MG, et al. Adalimumab ameliorates OVA-induced airway inflammation in mice: Role of CD4(+) CD25(+) FOXP3(+) regulatory T-cells. Eur J Pharmacol. 2016 Sep 5;786:100-108.
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Product Notes
The Adalimumab (Catalog #AAA5759546) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Adalimumab, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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