Structure
Spinorphin, Inhibitor
Spinorphin
Purity
100.00%
Synonyms
Spinorphin; inhibitor
Purity/Purification
100.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C45H64N8O10
SMILES
CC(C)C[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
CAS Number
137201-62-8
Target & IC50
enkephalin degrading enzymes
In Vitro
Spinorphin significantly inhibited the functions of polymorphonuclear neutrophils (PMNs) by suppressing the binding of fMLF to its receptor on PMNs. Further, this inhibitor suppressed the carrageenan-induced accumulation of PMN in mouse air pouches after intravenous administration. These results indicate that spinorphin may be an endogenous anti-inflammatory regulator. The possible role of spinorphin and its analog as regulators in pain and inflammation will be discussed[2].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for Spinorphin, inhibitor
Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.
Product Categories/Family for Spinorphin, inhibitor
References
Ayar A, Ozcan M, Kemal Tugrul Kuzgun, et al. Spinorphin inhibits membrane depolarization- and capsaicin-induced intracellular calcium signals in rat primary nociceptive dorsal root ganglion neurons in culture[J]. Journal of Receptor Research, 2015, 35(6):550-558.
Ayar A, Ozcan M, Kemal Tugrul Kuzgun, et al. Spinorphin inhibits membrane depolarization- and capsaicin-induced intracellular calcium signals in rat primary nociceptive dorsal root ganglion neurons in culture[J]. Journal of Receptor Research, 2015, 35(6):550-558.
YAMAMOTO,Y. Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation.[J]. Current Protn & Peptide ence, 2002, 3(6):-.
YAMAMOTO,Y. Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation.[J]. Current Protn & Peptide ence, 2002, 3(6):-.
Ayar A, Ozcan M, Kemal Tugrul Kuzgun, et al. Spinorphin inhibits membrane depolarization- and capsaicin-induced intracellular calcium signals in rat primary nociceptive dorsal root ganglion neurons in culture[J]. Journal of Receptor Research, 2015, 35(6):550-558.
YAMAMOTO,Y. Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation.[J]. Current Protn & Peptide ence, 2002, 3(6):-.
YAMAMOTO,Y. Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation.[J]. Current Protn & Peptide ence, 2002, 3(6):-.
Similar Products
Product Notes
The Spinorphin (Catalog #AAA5759250) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Spinorphin, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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