Dimethyl lithospermate B, Inhibitor

Dimethyl lithospermate B

Purity

98.00%

Synonyms

Dimethyl lithospermate B; dmLSB; inhibitor

Ordering
Cat. Num. AAA5759106 For Research Use Only!

Purity/Purification

98.00%

Form/Format

Solid. Powder

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C38H34O16

SMILES

COC([C@@H](Cc(cc1)cc(O)c1O)OC([C@H]1c2c(/C=C/C(O[C@H](Cc(cc3)cc(O)c3O)C(OC)=O)=O)ccc(O)c2O[C@@H]1c(cc1)cc(O)c1O)=O)=O

CAS Number

875313-64-7

Target & IC50

Sodium channel

In Vitro

Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to the increased inward current during the early phases of the action potential [1][2].

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Related Product Information for Dimethyl lithospermate B, inhibitor

Dimethyl lithospermate B is a selective Na+ channel agonist.

Product Categories/Family for Dimethyl lithospermate B, inhibitor

Membrane transporter/Ion channel; Sodium Channel

References

Fish JM, et al. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation. 2006 Mar 21;113(11):1393-400.
Fish JM, et al. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation. 2006 Mar 21;113(11):1393-400.
Yoon JY, et al. A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes. Br J Pharmacol. 2004 Nov;143(6):765-73.
Yoon JY, et al. A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes. Br J Pharmacol. 2004 Nov;143(6):765-73.

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Product Notes

The Dimethyl lithospermate B (Catalog #AAA5759106) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Dimethyl lithospermate B, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Dimethyl lithospermate B, Inhibitor