Structure
cangrelor tetrasodium, Inhibitor
cangrelor tetrasodium
Purity
100.00%
Synonyms
cangrelor tetrasodium; inhibitor
Purity/Purification
100.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C17H21Cl2F3N5Na4O12P3S2
SMILES
[Na+].[Na+].[Na+].[Na+].CSCCNc1nc(SCCC(F)(F)F)nc2n(cnc12)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)C(Cl)(Cl)P([O-])([O-])=O)[C@@H](O)[C@H]1O
CAS Number
163706-36-3
Target & IC50
GPR17
In Vitro
cangrelor, a non-sepesific GPR17 antagonist, alleviates pulmonary fibrosis partly by inhibiting macrophage inflammation in mice.Cangrelor is also a well-known anti-platelet agent. cangrelor (10mg/kg) not only significantly decreased BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreased the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice. In addition, cangrelor decreased the number of CD40 and MPO double positive neutrophils and the expression level of CD40 in BLM-treated mouse lungs[1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for cangrelor tetrasodium, inhibitor
Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects.
Product Categories/Family for cangrelor tetrasodium, inhibitor
References
Tianwei Zhan, Taofeng Wei.Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice.Mol Immunol. 2020 Apr;120:83-92.
Tianwei Zhan, Taofeng Wei.Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice.Mol Immunol. 2020 Apr;120:83-92.
K. Beko, B. Kovanyi, F. Goloncser, et al. Contribution of platelet P2Y12 receptors to chronic Complete Freund's adjuvant-induced inflammatory pain[J]. Journal of Thrombosis and Haemostasis, 2017.
K. Beko, B. Kovanyi, F. Goloncser, et al. Contribution of platelet P2Y12 receptors to chronic Complete Freund's adjuvant-induced inflammatory pain[J]. Journal of Thrombosis and Haemostasis, 2017.
Bhattad VB, et al. Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events. Ann Transl Med. 2019;7(17):408.
Bhattad VB, et al. Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events. Ann Transl Med. 2019;7(17):408.
Tianwei Zhan, Taofeng Wei.Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice.Mol Immunol. 2020 Apr;120:83-92.
K. Beko, B. Kovanyi, F. Goloncser, et al. Contribution of platelet P2Y12 receptors to chronic Complete Freund's adjuvant-induced inflammatory pain[J]. Journal of Thrombosis and Haemostasis, 2017.
K. Beko, B. Kovanyi, F. Goloncser, et al. Contribution of platelet P2Y12 receptors to chronic Complete Freund's adjuvant-induced inflammatory pain[J]. Journal of Thrombosis and Haemostasis, 2017.
Bhattad VB, et al. Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events. Ann Transl Med. 2019;7(17):408.
Bhattad VB, et al. Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events. Ann Transl Med. 2019;7(17):408.
Similar Products
Product Notes
The cangrelor tetrasodium (Catalog #AAA5758198) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "cangrelor tetrasodium, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
