Structure
Atopaxar hydrobromide, Inhibitor
Atopaxar hydrobromide
Purity
>98% (HPLC)
Synonyms
Atopaxar hydrobromide; E5555 hydrobromide; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 10mM (<1mg/mL refers to the product slightly soluble or insoluble)
Target
PAR
Receptor
PAR-1
Chemical Name
2-(5, 6-Diethoxy-7-fluoro-1, 3-dihydro-1-imino-2H-isoindol-2-yl)-1-[3-(1, 1-dimethylethyl)-4-methoxy-5-(4-morpholinyl)phenyl]ethanone hydrobromide
SMILES
COC1=C(N2CCOCC2)C=C(C(CN(CC3=C4C(F)=C(OCC)C(OCC)=C3)C4=N)=O)C=C1C(C)(C)C.[H]Br
Molecular Formula
C29H38FN3O5.HBr
CAS Number
474550-69-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Atopaxar hydrobromide, inhibitor
A potent, reversible PAR-1 antagonist with IC50 of 19nM; shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 of 64nM and 31nM, respectively, with no effect on platelet aggregation induced by either ADP or collagen; inhibits arterial thrombosis without affecting bleeding time in photochemically-induced thrombosis model guinea pigs.Thrombosis Phase 2 Clinical
Product Categories/Family for Atopaxar hydrobromide, inhibitor
References
1. Serebruany VL, et al. Thromb Haemost. 2009 Jul; 102 (1):111-9.
2. Angiolillo DJ, et al. Eur Heart J. 2010 Jan; 31 (1):17-28.
3. Kogushi M, et al. Eur J Pharmacol. 2011 Apr 25; 657 (1-3):131-7.
2. Angiolillo DJ, et al. Eur Heart J. 2010 Jan; 31 (1):17-28.
3. Kogushi M, et al. Eur J Pharmacol. 2011 Apr 25; 657 (1-3):131-7.
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Product Notes
The Atopaxar hydrobromide (Catalog #AAA3604575) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Atopaxar hydrobromide, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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