Pirenoxine, Inhibitor
Pirenoxine
Purity
98.00%
Synonyms
Pirenoxine; Catalin; PRX; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: Soluble
(<1mg/ refers to the product slightly soluble or insoluble)
(<1mg/ refers to the product slightly soluble or insoluble)
Formula
C16H8N2O5
SMILES
O=C(C1=CC(O)=C2C(C(C=C3OC4=C(N=C32)C=CC=C4)=O)=N1)O
CAS Number
1043-21-6
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Pirenoxine, inhibitor
Pirenoxine is an agent with anti-cataractogenesis activity by interacting with calcium ions or selenite which could lead to the formation of lens cataract.
References
Tsuneyoshi Y, Higuchi A, Negishi K, Tsubota K. Suppression of presbyopia progression with pirenoxine eye drops: experiments on rats and non-blinded, randomized clinical trial of efficacy. Sci Rep. 2017 Jul 28;7(1):6819. doi: 10.1038/s41598-017-07208-6. PubMed PMID: 28754903; PubMed Central PMCID: PMC5533700.
Ueno A, Yamaoka S, Ito Y, Kotake T, Nakazawa Y, Nagai N. Improvement of Dissolution Rate and Stability in a Pirenoxine Ophthalmic Suspension by the Bead Mill Methods. Yakugaku Zasshi. 2017;137(5):635-641. doi: 10.1248/yakushi.16-00267. Japanese. PubMed PMID: 28458295.
Liao Z, Yu X, Yao Q, Yi P. Interaction between pirenoxine and bovine serum albumin in aqueous solution. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Aug 14;129:314-9. doi: 10.1016/j.saa.2014.03.057. Epub 2014 Apr 1. PubMed PMID: 24747854.
Hu CC, Liao JH, Hsu KY, Lin IL, Tsai MH, Wu WH, Wei TT, Huang YS, Chiu SJ, Chen HY, Wu SH, Wu TH. Role of pirenoxine in the effects of catalin on in vitro ultraviolet-induced lens protein turbidity and selenite-induced cataractogenesis in vivo. Mol Vis. 2011;17:1862-70. Epub 2011 Jul 12. PubMed PMID: 21850160; PubMed Central PMCID: PMC3144730.
Ueno A, Yamaoka S, Ito Y, Kotake T, Nakazawa Y, Nagai N. Improvement of Dissolution Rate and Stability in a Pirenoxine Ophthalmic Suspension by the Bead Mill Methods. Yakugaku Zasshi. 2017;137(5):635-641. doi: 10.1248/yakushi.16-00267. Japanese. PubMed PMID: 28458295.
Liao Z, Yu X, Yao Q, Yi P. Interaction between pirenoxine and bovine serum albumin in aqueous solution. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Aug 14;129:314-9. doi: 10.1016/j.saa.2014.03.057. Epub 2014 Apr 1. PubMed PMID: 24747854.
Hu CC, Liao JH, Hsu KY, Lin IL, Tsai MH, Wu WH, Wei TT, Huang YS, Chiu SJ, Chen HY, Wu SH, Wu TH. Role of pirenoxine in the effects of catalin on in vitro ultraviolet-induced lens protein turbidity and selenite-induced cataractogenesis in vivo. Mol Vis. 2011;17:1862-70. Epub 2011 Jul 12. PubMed PMID: 21850160; PubMed Central PMCID: PMC3144730.
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Product Notes
The Pirenoxine (Catalog #AAA5756668) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Pirenoxine, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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