Structure
PYZD-4409, inhibitor
PYZD-4409
Purity
98.00%
Synonyms
PYZD-4409; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 35mg/mL (99.53mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C14H7ClFN3O5
SMILES
FC1=CC=C(N2C(/C(C(N2)=O)=C\C3=CC=C([N+]([O-])=O)O3)=O)C=C1Cl
CAS Number
423148-78-1
Target & IC50
ubiquitin-activating enzyme UBA1: ic50 20uM
In Vitro
PYZD-4409 (10mg/kg; intraperitoneal injection; daily on alternate days; for 16 days; male severe combined immunodeficient mice) reduces tumor weight and volume[1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for PYZD-4409, inhibitor
PYZD-4409 causes cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells. PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 (IC50: 20uM (cell-free enzymatic assay)).
References
Xu GW, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment,of leukemia and multiple myeloma. Blood. 2010 Mar 18;115(11):2251-9.
Xu GW, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment,of leukemia and multiple myeloma. Blood. 2010 Mar 18;115(11):2251-9.
Xu GW, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment,of leukemia and multiple myeloma. Blood. 2010 Mar 18;115(11):2251-9.
Similar Products
Product Notes
The PYZD-4409 (Catalog #AAA5755430) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PYZD-4409, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
