Structure
MSI-1436 lactate, Inhibitor | MSI-1436, inhibitor
MSI-1436 lactate
Purity
98.00%
Synonyms
MSI-1436 lactate; Trodusquemine lactate; Aminosterol-1436 lactate; MSI-1436; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 54mg/mL (53.99mM) Need ultrasonic and warming
H2O: 33.33mg/mL (33.32mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
H2O: 33.33mg/mL (33.32mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C37H72N4O5S.7/2C3H6O3
SMILES
NCCCNCCCCNCCCN[C@@H]1C[C@@](C[C@@H](O)[C@]2([H])[C@]3([H])CC[C@@]4(C)[C@@]2([H])CC[C@@]4([C@H](C)CC[C@@H](OS(=O)(O)=O)C(C)C)[H])([H])[C@]3(C)CC1.O=C(O)C(C)O.[3.5]
CAS Number
1309370-86-2
Target & IC50
PTB1B: ic50 1uM
TCPTP: ic50 224uM
TCPTP: ic50 224uM
In Vitro
Trodusquemine significantly enhanced insulin-stimulated tyrosine phosphorylation of insulin receptor (IR) beta and STAT3, direct targets of PTP1B, in HepG2 cells in vitro and/or hypothalamic tissue[1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for MSI-1436, inhibitor
MSI-1436 lactate is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1uM)
References
Lantz KA, et al. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring). 2010 Aug;18(8):1516-1523.
Lantz KA, et al. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring). 2010 Aug;18(8):1516-1523.
Qin Z, et al. Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling. Neuron. 2015 Mar 18;85(6):1319-31.
Qin Z, et al. Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling. Neuron. 2015 Mar 18;85(6):1319-31.
Qin Z, et al. Functional properties of Claramine: a novel PTP1B inhibitor and mimetic compound. Biochem Biophys Res Commun. 2015 Feb 27;458(1):21-7.
Qin Z, et al. Functional properties of Claramine: a novel PTP1B inhibitor and mimetic compound. Biochem Biophys Res Commun. 2015 Feb 27;458(1):21-7.
Lantz KA, et al. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring). 2010 Aug;18(8):1516-1523.
Qin Z, et al. Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling. Neuron. 2015 Mar 18;85(6):1319-31.
Qin Z, et al. Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling. Neuron. 2015 Mar 18;85(6):1319-31.
Qin Z, et al. Functional properties of Claramine: a novel PTP1B inhibitor and mimetic compound. Biochem Biophys Res Commun. 2015 Feb 27;458(1):21-7.
Qin Z, et al. Functional properties of Claramine: a novel PTP1B inhibitor and mimetic compound. Biochem Biophys Res Commun. 2015 Feb 27;458(1):21-7.
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Product Notes
The MSI-1436 (Catalog #AAA5753528) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MSI-1436 lactate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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