Structure

Ibiglustat L-Malic acid, Inhibitor

Ibiglustat L-Malic acid

Purity

98.00%

Synonyms

Ibiglustat L-Malic acid; Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid); inhibitor

Ordering
Cat. Num. AAA5753300 For Research Use Only!

Purity/Purification

98.00%

Form/Format

Solid. Powder

Solubility

DMSO: 100mg/mL (191.00mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H30FN3O7S

SMILES

O=C(O[C@@H]1CN2CCC1CC2)NC(C)(C3=CSC(C4=CC=C(F)C=C4)=N3)C.OC(C[C@H](O)C(O)=O)=O

CAS Number

1629063-78-0

Target & IC50

Glucosylceramide synthase

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Structure

Related Product Information for Ibiglustat L-Malic acid, inhibitor

Ibiglustat L-Malic acid (Venglustat L-Malic acid) is a selective, allosteric inhibitor of glucosylceramide synthase (GCS) with the ability to cross the blood-brain barrier. It can be used for the research of PD Parkinson's disease, SRT in Fabry's and Gaucher's.

Product Categories/Family for Ibiglustat L-Malic acid, inhibitor

Metabolism; Transferase

References

WO 2015089067 A1.
WO 2015089067 A1.
Iva Stojkovska, et al. Molecular mechanisms of alpha-synuclein and GBA1 in Parkinson's disease. Cell Tissue Res. 2017.
Iva Stojkovska, et al. Molecular mechanisms of alpha-synuclein and GBA1 in Parkinson's disease. Cell Tissue Res. 2017.
Christoph Arenz, et al. Recent advances and novel treatment, for sphingolipidoses. Future Med. Chem. (2017) 9(14), 1687-1700.
Christoph Arenz, et al. Recent advances and novel treatment, for sphingolipidoses. Future Med. Chem. (2017) 9(14), 1687-1700.
Itier JM, et al. Effective clearance of GL-3 in a human iPSC-derived cardiomyocyte model of Fabry disease. J Inherit Metab Dis. 2014 Nov;37(6):1013-22.
Itier JM, et al. Effective clearance of GL-3 in a human iPSC-derived cardiomyocyte model of Fabry disease. J Inherit Metab Dis. 2014 Nov;37(6):1013-22.

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Product Notes

The Ibiglustat L-Malic acid (Catalog #AAA5753300) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ibiglustat L-Malic acid, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Ibiglustat L-Malic acid, Inhibitor