Structure
TAK-960, inhibitor
TAK-960
Purity
98.00%
Synonyms
TAK-960; inhibitor
Purity/Purification
98.00%
Form/Format
Powder
Formula
C27H34F3N7O3
CAS
1137868-52-0
Smiles
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc2N(C)C(=O)C(F)(F)CN(C3CCCC3)c2n1
Receptor (IC50)
Plk1: 0.8nM
Plk2: 16.9nM
Plk3: 50.2nM
Plk2: 16.9nM
Plk3: 50.2nM
Solubility
DMSO: 35mg/mL (62.32mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Structure
Structure
Related Product Information for TAK-960, inhibitor
TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2nM for Plk1, Plk2, and Plk3, respectively.
Product Categories/Family for TAK-960, inhibitor
References
1. Klauck P J, Bagby S M, Capasso A, et al. Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer[J]. BMC Cancer, 2018, 18 (1):136.
2. Hikichi Y, Honda K, Hikami K,et al.TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens[J].Mol Cancer Ther. 2012 Mar;11 (3):700-9.
3. Nie Z, Feher V, Natala S, et al. Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1).[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23 (12):3662-3666.
4. Inoue M, et al. PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase. Sci Rep. 2015 Oct 27;5:15666.
2. Hikichi Y, Honda K, Hikami K,et al.TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens[J].Mol Cancer Ther. 2012 Mar;11 (3):700-9.
3. Nie Z, Feher V, Natala S, et al. Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1).[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23 (12):3662-3666.
4. Inoue M, et al. PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase. Sci Rep. 2015 Oct 27;5:15666.
Similar Products
Product Notes
The TAK-960 (Catalog #AAA5752404) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TAK-960, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
