Cathepsin S Active Protein | CTSS active protein

Cathepsin S (human), (recombinant)

Cat. Num. AAA566655

• Purity: >=95% (SDS-PAGE); Purified by multi-step chromatography
• Synonyms: Cathepsin S; Cathepsin S (human); (recombinant); CTSS active protein

• Host: Insect cells
• Purity/Purification: >=95% (SDS-PAGE); Purified by multi-step chromatography
• Form/Format: Liquid. In 100 mM MES, pH6.5, containing 1 mM EDTA, 50 mM L-cysteine, 10 mM DTT, 0.5% TritonX-100, 30% glycerol

• Source Note: Recombinant active cathepsin S cloned from human cDNA as full length proenzyme, auto-activated by incubation in pH4.5 acetate buffer, and purified. Produced in a baculovirus expression system
• Specific Activity: >=20U/mg protein. One unit will hydrolyze oneuMole Z-Val-Val-Arg-AMC substrate (40uM) per minute at 37 degree C
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: For long term storage, store at -80 degree C; Shipping: Shipped on Dry Ice

Related Product Information for CTSS active protein

Cathepsin S, a member of the papain family of lysosomal cysteine proteases, functions in the immune system.

Product Categories/Family for CTSS active protein

Proteostasis; Proteolysis & Protein Degradation

NCBI and Uniprot Product Information

• NCBI GI #: 315075311
• NCBI GeneID: 1520
• NCBI Accession #: NP_001186668.1
• NCBI GenBank Nucleotide #: NM_001199739.1
• UniProt Accession #: P25774; Q5T5I0; Q6FHS5; Q9BUG3; B4DWC9; D3DV05
• Molecular Weight: 37,496 Da
• NCBI Official Full Name: cathepsin S isoform 2 preproprotein
• NCBI Official Synonym Full Names: cathepsin S
• NCBI Official Symbol: CTSS
• NCBI Protein Information: cathepsin S
• UniProt Protein Name: Cathepsin S
• Protein Family: Cathepsin
• UniProt Gene Name: CTSS
• UniProt Entry Name: CATS_HUMAN

NCBI Description

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Uniprot Description

CTSS: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. Belongs to the peptidase C1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.22.27

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: lysosomal lumen; extracellular space; intracellular membrane-bound organelle; membrane; lysosome; extracellular region

Molecular Function: collagen binding; proteoglycan binding; cysteine-type endopeptidase activity; fibronectin binding; laminin binding

Biological Process: adaptive immune response; extracellular matrix organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis; collagen catabolic process; antigen processing and presentation; extracellular matrix disassembly; antigen processing and presentation of peptide antigen via MHC class I; proteolysis involved in cellular protein catabolic process; toll-like receptor signaling pathway; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response; positive regulation of inflammatory response