Growth Hormone Recombinant Protein | GH1 recombinant protein
Mouse Growth Hormone Recombinant
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Recombinant GH is a disulfide-linked homodimeric protein consisting of 191 amino acid residue subunits, and migrates as an approximately 22 kDa protein under non-reducing and reducing conditions in SDS-PAGE.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
• statement by the Growth Hormone research society on the gh/igf-i axis in extending health span .J Gerontol A Biol Sci Med Sci, Oct 2009; 64A: 1039 - 1044.
• the p561t polymorphism of the Growth Hormone receptor gene has an inhibitory effect on mandibular growth in young children .Eur J Orthod, Oct 2009; 31: 536 - 541.
• central ghrelin regulates peripheral lipid metabolism in a Growth Hormone-independent fashion .Endocrinology, Oct 2009; 150: 4562 - 4574.
• effects of syndyphalin-33 on feed intake and circulating measures of Growth Hormone, cortisol, and immune cell populations in the recently weaned pig .J Anim Sci, Oct 2009; 87: 3218 - 3225.
NCBI and Uniprot Product Information
Uniprot Description
GH: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A); also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH. Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH. Defects in GH1 are the cause of Kowarski syndrome (KWKS); also known as pituitary dwarfism VI. Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2). IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. Belongs to the somatotropin/prolactin family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Hormone; Secreted, signal peptide
Cellular Component: extracellular space; mitochondrion; plasma membrane; extracellular region; trans-Golgi network; cytosol; nucleus; secretory granule
Molecular Function: growth hormone receptor binding; metal ion binding; hormone activity
Biological Process: response to food; response to light stimulus; positive regulation of neurogenesis; cellular response to insulin stimulus; neuroblast proliferation; glucose transport; positive regulation of multicellular organism growth; regulation of steroid hormone receptor signaling pathway; signal transduction; positive regulation of growth; alveolus development
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Product Notes
The GH1 gh1 (Catalog #AAA553233) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MATDSRTSWL LTVSLLCLLW PQEASAFPAM PLSSLFSNAV LRAQHLHQLA ADTYKEFERA YIPEGQRYSI QNAQAAFCFS ETIPAPTGKE EAQQRTDMEL LRFSLLLIQS WLGPVQFLSR IFTNSLMFGT SDRVYEKLKD LEEGIQALMQ ELEDGSPRVG QILKQTYDKF DANMRSDDAL LKNYGLLSCF KKDLHKAETY LRVMKCRRFV ESSCAF. It is sometimes possible for the material contained within the vial of "Growth Hormone, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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