MCP-4 (CCL13) Recombinant Protein | MCP-4 recombinant protein
Human MCP-4 (CCL13) Recombinant
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
and propeptide and has a calculated molecular mass of approximately 9 kDa.
Recombinant MCP-4 is a disulfide-linked monomeric protein consisting of 76 amino acid residue subunits and migrates as an approximately 9 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
• monocyte chemoattractant protein-4 (MCP-4) /ccl13 is highly expressed in cartilage from patients with rheumatoid arthritis .Rheumatology, Apr 2006; 45: 421 - 424.
• il-4 differentially regulates eotaxin and MCP-4 in lung epithelium and circulating mononuclear cells .Am J Physiol Lung Cell Mol Physiol, Nov 2001; 281: 1288.
• monocyte chemoattractant protein (mcp) -4 expression in the airways of patients with asthma. induction in epithelial cells and mononuclear cells by proinflammatory cytokines .Am. J. Respir. Crit. Care Med., Aug 2000; 162: 723 - 732.
• eosinophil chemotactic chemokines (eotaxin, eotaxin-2, rantes, monocyte chemoattractant protein-3 (mcp-3), and MCP-4), and c-c chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (intrinsic) asthmatics .J. Immunol., Dec 1999; 163: 6321 - 6329.
NCBI and Uniprot Product Information
NCBI Description
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]
Uniprot Description
CCL13: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Secreted, signal peptide; Chemokine; Motility/polarity/chemotaxis; Secreted
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: extracellular space
Molecular Function: chemokine activity; receptor binding
Biological Process: cellular calcium ion homeostasis; regulation of cell shape; cell-cell signaling; eosinophil chemotaxis; immune response; cytoskeleton organization and biogenesis; inflammatory response; chemotaxis; signal transduction
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Product Notes
The MCP-4 ccl13 (Catalog #AAA553048) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MKVSAVLLCL LLMTAAFNPQ GLAQPDALNV PSTCCFTFSS KKISLQRLKS YVITTSRCPQ KAVIFRTKLG KEICADPKEK WVQNYMKHLG RKAHTLKT. It is sometimes possible for the material contained within the vial of "MCP-4 (CCL13), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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