Bone Morphogenetic Protein-2 Active Protein | BMP2 active protein
Recombinant Human Bone MorphogeneticProtein-2 (rHu BMP-2)
Gene Names
BMP2; BDA2; BMP2A
Purity
>95% by SDS-PAGE and HPLC analyses.
Synonyms
Bone Morphogenetic Protein-2; Recombinant Human Bone MorphogeneticProtein-2 (rHu BMP-2); human BMP-2; Human Bone Morphogenetic Protein 2 (BMP-2); BMP2 active protein
Host
E Coli
Purity/Purification
>95% by SDS-PAGE and HPLC analyses.
Form/Format
Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution containing 10mM sodium citrate pH 3.5.
Physical Appearance: Sterile FilteredWhite lyophilized (freeze-dried) powder.
Physical Appearance: Sterile FilteredWhite lyophilized (freeze-dried) powder.
Sequence Length
396
Molecular Weight Information
Approximately 23.9 kDa, a single non-glycosylated polypeptide chain containing 209 amino acids.
Biological Activity
Fully biologically active when compared to standard. The ED50 as determined by the cytolysis of MC3T3-E1 cells is less than 50 ng/ml.
Endotoxin Level
Less than 1EU/mg of rHuBMP-2 as determined by LAL method.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10mM HAc to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions.
Preparation and Storage
Store in room temperature.
Related Product Information for BMP2 active protein
BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
44,702 Da
NCBI Official Full Name
bone morphogenetic protein 2 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 2
NCBI Official Symbol
BMP2
NCBI Official Synonym Symbols
BDA2; BMP2A
NCBI Protein Information
bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A
UniProt Protein Name
Bone morphogenetic protein 2
Protein Family
UniProt Gene Name
BMP2
UniProt Synonym Gene Names
BMP2A; BMP-2; BMP-2A
UniProt Entry Name
BMP2_HUMAN
NCBI Description
The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Induces cartilage and bone formation.
Subunit structure: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN
By similarity. Ref.4
Subcellular location: Secreted.
Tissue specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Pharmaceutical use: Available under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft fractures.
Sequence similarities: Belongs to the TGF-beta family.
Research Articles on BMP2
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Product Notes
The BMP2 bmp2 (Catalog #AAA546125) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Bone Morphogenetic Protein-2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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