Rabbit PDE4B Polyclonal Antibody | anti-PDE4B antibody
PDE4B Antibody
Gene Names
PDE4B; DPDE4; PDEIVB
Reactivity
Human, Mouse, Rat
Applications
ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Synonyms
PDE4B; Polyclonal Antibody; PDE4B Antibody; 5''-cyclic phosphodiesterase 4B; cAMP-specific 3''; cAMP-specific 3'; 5'-cyclic phosphodiesterase 4B; DPDE4; dunce-like phosphodiesterase E4; MGC126529; PDE 4B; PDE IVB; PDE32; PDE4B5; PDEIVB; Phosphodiesterase 4B; Phosphodiesterase-4B cAMP-specific (dunce (Drosophila)-homolog) antibody; anti-PDE4B antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
This antibody detects all PDE4B proteins, including PDE4B1, PDE4B2, PDE4B3, and a 66 kDa PDE4B variant. It does not cross-react with other PDE family members such as PDE4A, PDE4C, or PDE4D.
Form/Format
Affinity Purified
Concentration
0.68 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
736
Applicable Applications for anti-PDE4B antibody
Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes
Confocal Microscopy||1:250
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:250
Immunofluorescence: 1:250
Immunohistochemistry: 1:250
Immunoprecipitation: 1:350
Western Blot: 1:500-1:1,000
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:250
Immunofluorescence: 1:250
Immunohistochemistry: 1:250
Immunoprecipitation: 1:350
Western Blot: 1:500-1:1,000
Immunogen
Synthetic peptide common to all PDE4B subtypes taken near N-terminal
Expression
Expressed in brain, heart, lung and skeletal muscle.
Determinant
N-epitope
Molecular Function
Hydrolase, 3', 5'-cyclic-AMP phosphodiesterase activity, cAMP binding
Preparation and Storage
-20 degree C for long term storage
Related Product Information for anti-PDE4B antibody
Affinity Purified cAMP-specific 3', 5'-cyclic phosphodiesterase 4B Antibody N-epitope
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory
Product Categories/Family for anti-PDE4B antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
57,709 Da
NCBI Official Full Name
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
NCBI Official Synonym Full Names
phosphodiesterase 4B
NCBI Official Symbol
PDE4B
NCBI Official Synonym Symbols
DPDE4; PDEIVB
NCBI Protein Information
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
UniProt Protein Name
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Protein Family
UniProt Gene Name
PDE4B
UniProt Synonym Gene Names
DPDE4
UniProt Entry Name
PDE4B_HUMAN
NCBI Description
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Uniprot Description
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Research Articles on PDE4B
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Product Notes
The PDE4B pde4b (Catalog #AAA543498) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PDE4B Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PDE4B can be used in a range of immunoassay formats including, but not limited to, Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). Confocal Microscopy||1:250 Dot Blot: 1:10,000 ELISA: 1:10,000 Immunocytochemistry: 1:250 Immunofluorescence: 1:250 Immunohistochemistry: 1:250 Immunoprecipitation: 1:350 Western Blot: 1:500-1:1,000. Researchers should empirically determine the suitability of the PDE4B pde4b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDE4B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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