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Rabbit anti-Human HE4 Polyclonal Antibody | anti-HE4 antibody

HE4 Antibody BIOTIN-Conjugated

Gene Names
WFDC2; HE4; WAP5; EDDM4; dJ461P17.6
Reactivity
Human
Applications
ELISA, Western Blot
Synonyms
HE4; Polyclonal Antibody; HE4 Antibody BIOTIN-Conjugated; EDDM4; epididymal protein 4; Epididymal secretory protein E4; Epididymis specific whey acidic protein type four disulfide core; HE 4; Major epididymis specific protein E4; Putative protease inhibitor WAP5; WAP domain containing protein HE4; WAP four disulfide core domain 2; WAP5; WFDC2 antibody; anti-HE4 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Form/Format
BIOTIN-Conjugated
Concentration
0.68 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
124
Applicable Applications for anti-HE4 antibody
ELISA (EIA), IMM, Western Blot (WB)
Application Notes
Dot Blot: 1:20,000
ELISA: 1:20,000
Immunoprecipitation: 1:200
Western Blot: 1:500-1:750
Immunogen
Synthetic peptide taken within amino acid region 50-100 on human WAP four-disulfide core domain protein 2.
Expression
male reproductive system; regions of the respiratory tract; nasopharynx; number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines.Initially described as being exclusively transcribed in the epididymis
Determinant
N-epitope
Molecular Function
Aspartic protease inhibitor, Protease inhibitor, Serine protease inhibitor, Thiol protease inhibitor
Structure
Homotrimer; disulfide-linked
Subcellular Location
Extracellular space; Extracellular vesicular exosome; Secreted
Preparation and Storage
-20 degree C for long term storage
Related Product Information for anti-HE4 antibody
BIOTIN-Conjugated WAP domain containing protein HE4-V2/V3 Antibody N-epitope
Broad range protease inhibitor

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
11,043 Da
NCBI Official Full Name
WAP four-disulfide core domain protein 2
NCBI Official Synonym Full Names
WAP four-disulfide core domain 2
NCBI Official Symbol
WFDC2
NCBI Official Synonym Symbols
HE4; WAP5; EDDM4; dJ461P17.6
NCBI Protein Information
WAP four-disulfide core domain protein 2
UniProt Protein Name
WAP four-disulfide core domain protein 2
UniProt Gene Name
WFDC2
UniProt Synonym Gene Names
HE4; WAP5
UniProt Entry Name
WFDC2_HUMAN

NCBI Description

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

Uniprot Description

WFDC2: a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: extracellular space

Molecular Function: aspartic-type endopeptidase inhibitor activity; cysteine protease inhibitor activity; endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity

Biological Process: proteolysis; spermatogenesis

Research Articles on HE4

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Product Notes

The HE4 wfdc2 (Catalog #AAA541555) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HE4 Antibody BIOTIN-Conjugated reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HE4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), IMM, Western Blot (WB). Dot Blot: 1:20,000 ELISA: 1:20,000 Immunoprecipitation: 1:200 Western Blot: 1:500-1:750. Researchers should empirically determine the suitability of the HE4 wfdc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HE4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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