Rabbit CCK4 / PTK7 Polyclonal Antibody | anti-CCK4 / PTK7 antibody
CCK4 / PTK7 Antibody BIOTIN-Conjugated
ELISA: 1:10,000
Immunofluorescence: 1:100
Western Blot: 1:500
Activator of JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
Uniprot Description
DLK: May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.25; Protein kinase, TKL; TKL group; MLK family; LZK subfamily
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: axon; cytoplasm; cytosol; growth cone; membrane; plasma membrane
Molecular Function: ATP binding; MAP kinase kinase kinase activity; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity
Biological Process: activation of MAPKK activity; histone phosphorylation; JNK cascade; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation
Research Articles on CCK4 / PTK7
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Product Notes
The CCK4 / PTK7 map3k12 (Catalog #AAA541162) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CCK4 / PTK7 Antibody BIOTIN-Conjugated reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CCK4 / PTK7 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Immunofluorescence: 1:100 Western Blot: 1:500. Researchers should empirically determine the suitability of the CCK4 / PTK7 map3k12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CCK4 / PTK7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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