Rabbit Phospho-PDE3B Polyclonal Antibody | anti-PDE3B antibody
Phospho PDE3B Antibody Affinity Purified
ELISA: 1:10,000
Western Blot: 1:500
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3.
NCBI and Uniprot Product Information
Uniprot Description
PDE3B: a cGMP-inhibited phosphodiesterase 1 involved in fat metabolism. Inhibition of PDE3B can augment PDE4 inhibitor-induced apoptosis in some patients with chronic lymphocytic leukemia.
Protein type: Phosphodiesterase; Membrane protein, multi-pass; EC 3.1.4.17; Nucleotide Metabolism - purine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11p15.1
Cellular Component: cytosol; endoplasmic reticulum; Golgi apparatus; integral to membrane; membrane
Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; metal ion binding; protein binding; protein kinase B binding
Biological Process: angiogenesis; cAMP catabolic process; cellular response to insulin stimulus; negative regulation of angiogenesis; negative regulation of cell adhesion; negative regulation of cell adhesion mediated by integrin; negative regulation of lipid catabolic process; signal transduction
Research Articles on PDE3B
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Product Notes
The PDE3B pde3b (Catalog #AAA540874) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho PDE3B Antibody Affinity Purified reacts with Chicken, Human, Monkey, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Phospho-PDE3B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), IMM, Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Western Blot: 1:500. Researchers should empirically determine the suitability of the PDE3B pde3b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phospho-PDE3B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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