Rabbit RASD2 Polyclonal Antibody | anti-RASD2 antibody
RASD2 Antibody
Gene Names
Rasd2; Rhes; TEM2; TEM-2; AU045414; 4930526B11Rik
Reactivity
Human, Monkey, Mouse, Rat
Applications
Dot Blot, ELISA, Immunoprecipitation, Western Blot
Synonyms
RASD2; Polyclonal Antibody; RASD2 Antibody; GTP binding protein Rhes antibody; MGC:4834 antibody; OTTHUMP00000197925 antibody; Ras homolog enriched in striatum antibody; RASD2 antibody; Rhes antibody; TEM2 antibody; Tumor endothelial marker 2 antibody; anti-RASD2 antibody
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat
Clonality
Polyclonal
Form/Format
Affinity Purified Immunoglobulins
Concentration
0.75 mg/ml IgG in antibody stabilization buffer (varies by lot)
Applicable Applications for anti-RASD2 antibody
Dot Blot (DB), ELISA, Immunoprecipitation (IP), Western Blot (WB)
Application Notes
Recommended Dilutions:
DOT Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:500
Western Blot: 1:500
DOT Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:500
Western Blot: 1:500
Immunogen
Synthetic peptide taken within amino acid region 250-325 on Rhes protein.
Preparation and Storage
Store at -20°C for long term storage.
Related Product Information for anti-RASD2 antibody
Descripition: Ras homolog enriched in striatum Antibody Affinity Purified
Overview: Ras homolog enriched in striatum (RHES), belongs to the RASD subfamily of the Ras-related GTP-binding protein superfamily. By responding to extracellular signals, these proteins regulate intracellular signaling pathways, thereby controlling essential cellular functions such as cell growth, gene transcription, cytoskeleton organization and pathways involved in synaptic plasticity, learning and memory (1). RHES, located on mouse chromosome 8, is a product of thyroid hormone-regulated gene during brain development and it regulates signal transduction from G protein-coupled receptors (2). It is implicated in cAMP/PKA signaling pathway- Rhes has been shown to inhibit the cAMP/PKA pathway by thyroid-stimulating hormone (3). Furthermore, RHES modulates dopamine signaling in the striatum- It is essential for correct dopamine-mediated GTP binding (4).
Studies investigating the role of RHES have shown that mice that are deficient in this protein were smaller than the wild type mice (1). These mice also showed behavioral abnormalities such as gender-dependent increase in anxiety levels and lack of clear motor coordination. Such studies also showed that absence of RHES modulated cAMP/PKA signaling in projection neurons by increasing golf protein levels (2). RHES is expressed in brain areas that receive dopaminergic input, such as striatum. Therefore, its mRNA expression is controlled by dopamine and its expression is reduced under conditions of dopamine supersensitivity (5). RHES has also been shown to bind Huntingtin and mutant Huntingtin protein (6). Expansion of Huntingtin is usually seen in patients with Huntington’s disease.
The Rhes antibodies were generated using peptide corresponding to mouse Rhes protein. Rhes antibodies are affinity purified over immobilized antigen based affinity chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer. RHES antibodies will label bands at 48 and 30 kDa which are absent in knockout mice. RHES positive control (PC-RHES) is available in ready-to-use SDS sample buffer. Synthetic peptide (P-RHES) for immunocompetition/immunodepletion assays are also available.
Overview: Ras homolog enriched in striatum (RHES), belongs to the RASD subfamily of the Ras-related GTP-binding protein superfamily. By responding to extracellular signals, these proteins regulate intracellular signaling pathways, thereby controlling essential cellular functions such as cell growth, gene transcription, cytoskeleton organization and pathways involved in synaptic plasticity, learning and memory (1). RHES, located on mouse chromosome 8, is a product of thyroid hormone-regulated gene during brain development and it regulates signal transduction from G protein-coupled receptors (2). It is implicated in cAMP/PKA signaling pathway- Rhes has been shown to inhibit the cAMP/PKA pathway by thyroid-stimulating hormone (3). Furthermore, RHES modulates dopamine signaling in the striatum- It is essential for correct dopamine-mediated GTP binding (4).
Studies investigating the role of RHES have shown that mice that are deficient in this protein were smaller than the wild type mice (1). These mice also showed behavioral abnormalities such as gender-dependent increase in anxiety levels and lack of clear motor coordination. Such studies also showed that absence of RHES modulated cAMP/PKA signaling in projection neurons by increasing golf protein levels (2). RHES is expressed in brain areas that receive dopaminergic input, such as striatum. Therefore, its mRNA expression is controlled by dopamine and its expression is reduced under conditions of dopamine supersensitivity (5). RHES has also been shown to bind Huntingtin and mutant Huntingtin protein (6). Expansion of Huntingtin is usually seen in patients with Huntington’s disease.
The Rhes antibodies were generated using peptide corresponding to mouse Rhes protein. Rhes antibodies are affinity purified over immobilized antigen based affinity chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer. RHES antibodies will label bands at 48 and 30 kDa which are absent in knockout mice. RHES positive control (PC-RHES) is available in ready-to-use SDS sample buffer. Synthetic peptide (P-RHES) for immunocompetition/immunodepletion assays are also available.
Product Categories/Family for anti-RASD2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
Rasd2 protein, partial
NCBI Official Synonym Full Names
RASD family, member 2
NCBI Official Symbol
Rasd2
NCBI Official Synonym Symbols
Rhes; TEM2; TEM-2; AU045414; 4930526B11Rik
NCBI Protein Information
GTP-binding protein Rhes
UniProt Protein Name
Rasd2 protein
Protein Family
UniProt Gene Name
Rasd2
UniProt Entry Name
Q8JZW1_MOUSE
Research Articles on RASD2
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Product Notes
The RASD2 rasd2 (Catalog #AAA540632) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RASD2 Antibody reacts with Human, Monkey, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's RASD2 can be used in a range of immunoassay formats including, but not limited to, Dot Blot (DB), ELISA, Immunoprecipitation (IP), Western Blot (WB). Recommended Dilutions: DOT Blot: 1:10,000 ELISA: 1:10,000 Immunoprecipitation: 1:500 Western Blot: 1:500. Researchers should empirically determine the suitability of the RASD2 rasd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RASD2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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