Rabbit anti-Human SorLA Polyclonal Antibody | anti-SorLA antibody
SorLA Antibody Affinity Purified
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500
Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization, as well as the establishment of embryonic organ systems.
NCBI and Uniprot Product Information
Uniprot Description
SORL1: Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Belongs to the VPS10-related sortilin family. SORL1 subfamily.
Protein type: Receptor, misc.; Cell surface; Membrane protein, integral
Cellular Component: cell soma; early endosome; endoplasmic reticulum; endosome; extracellular region; extracellular space; Golgi apparatus; Golgi cisterna; integral to membrane; membrane; multivesicular body; nuclear envelope lumen; perinuclear region of cytoplasm; recycling endosome; trans-Golgi network
Molecular Function: ADP-ribosylation factor binding; beta-amyloid binding; low-density lipoprotein binding; protein binding
Biological Process: cell migration; cholesterol metabolic process; endocytosis; lipid metabolic process; lipid transport; multicellular organismal development; negative regulation of MAP kinase activity; negative regulation of neurogenesis; negative regulation of protein binding; negative regulation of protein oligomerization; positive regulation of protein catabolic process; post-Golgi vesicle-mediated transport; protein maturation; protein retention in Golgi; protein targeting; protein targeting to Golgi; protein targeting to lysosome; regulation of smooth muscle cell migration; steroid metabolic process; transport
Research Articles on SorLA
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Product Notes
The SorLA sorl1 (Catalog #AAA540609) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SorLA Antibody Affinity Purified reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SorLA can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), IMM, Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Immunoprecipitation: 1:200 Western Blot: 1:500. Researchers should empirically determine the suitability of the SorLA sorl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SorLA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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