Rabbit anti-Human Syncytin 2 Polyclonal Antibody | anti-ERVFRD-1 antibody
Syncytin 2 Antibody FITC
Gene Names
ERVFRD-1; envFRD; UNQ6191; ERVFRDE1; GLLL6191; HERV-FRD; HERV-W/FRD
Reactivity
Human
Applications
ELISA, Immunoprecipitation, Western Blot
Purity
Immobilized antigen affinity chromatography
Synonyms
Syncytin 2; Polyclonal Antibody; Syncytin 2 Antibody FITC; Endogenous retrovirus group FRD member 1 antibody; Envelope polyprotein antibody; ERVFRD-1 antibody; HERV FRD 6p24.1 provirus ancestral Env polyprotein antibody; HERV FRD antibody; HERV FRD provirus ancestral Env polyprotein antibody; SU antibody; Syncytin 2 antibody; Syncytin B antibody; TM antibody; Transmembrane protein antibody; UNQ6191 antibody; anti-ERVFRD-1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immobilized antigen affinity chromatography
Concentration
0.5 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
538
Applicable Applications for anti-ERVFRD-1 antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes
ELISA: 1:50,000
IP: 1:200
WB: 1:500
IP: 1:200
WB: 1:500
Immunogen
Synthetic peptide taken within amino acid region 80-130 on human Syncytin-2 protein.
Conjugation
FITC
Molecular Function
Syncytium formation
Subcellular Location
Virion; Cell membrane
Preparation and Storage
Store at -20 degree C for long term storage.
Related Product Information for anti-ERVFRD-1 antibody
Overview: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732).1 Publication
Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139).
Structure: Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo.
Expression: Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea.
Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139).
Structure: Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo.
Expression: Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
59,523 Da
NCBI Official Full Name
syncytin-2 preproprotein
NCBI Official Synonym Full Names
endogenous retrovirus group FRD member 1, envelope
NCBI Official Symbol
ERVFRD-1
NCBI Official Synonym Symbols
envFRD; UNQ6191; ERVFRDE1; GLLL6191; HERV-FRD; HERV-W/FRD
NCBI Protein Information
syncytin-2
UniProt Protein Name
Syncytin-2
Protein Family
UniProt Gene Name
ERVFRD-1
UniProt Synonym Gene Names
ERVFRDE1; SU; TM
NCBI Description
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012]
Uniprot Description
This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732).
Research Articles on ERVFRD-1
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Product Notes
The ERVFRD-1 ervfrd-1 (Catalog #AAA5400818) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Syncytin 2 Antibody FITC reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Syncytin 2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB). ELISA: 1:50,000 IP: 1:200 WB: 1:500. Researchers should empirically determine the suitability of the ERVFRD-1 ervfrd-1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Syncytin 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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