HIPK2 blocking peptide

HIPK2 Blocking Peptide

Cat. Num. AAA5400608

• Gene Names: HIPK2; PRO0593
• Applications: Immunodepletion, Immunocompetition
• Purity: Immobilized antigen affinity chromatography
• Synonyms: HIPK2; HIPK2 Blocking Peptide; Antigenic Blocking Peptide Homeodomain-interacting protein kinase 2 Antibody; HIPK 2 antibody; Homeodomain interacting protein kinase 2 antibody; Nbak1 antibody; Nuclear body-associated kinase 1 antibody; PRO0593 antibody; Sialophorin tail-associated nuclear serine/threonine-protein kinase antibody; Stank antibody; HIPK2 blocking peptide

• Purity/Purification: Immobilized antigen affinity chromatography
• Sequence Length: 1171

• Applicable Applications for HIPK2 blocking peptide: Immunodepletion, Immunocompetition
• Molecular Function: ATP binding protein kinase activity protein serine/threonine kinase activity RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity SMAD binding transcription corepressor activity virion bindin
• Subcellular Location: Nucleus; PML body; Cytoplasm
• Preparation and Storage: Store at -20 degree C for long term storage.

Related Product Information for HIPK2 blocking peptide

Overview: Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A.

Peptide Description: Synthetic peptide taken within amino acid region 1150-1198 on human Homeodomain-interacting protein kinase 2 protein.

Expression: Highly expressed in heart, muscle and kidney. Weakly expressed in a ubiquitous way. Down-regulated in several thyroid and breast tumors.

NCBI and Uniprot Product Information

• NCBI GI #: 164420691
• NCBI GeneID: 28996
• NCBI Accession #: NP_001106710.1
• NCBI GenBank Nucleotide #: NM_001113239.2
• UniProt Accession #: Q9H2X6; Q75MR7; Q8WWI4; Q9H2Y1
• Molecular Weight: 128,158 Da
• NCBI Official Full Name: homeodomain-interacting protein kinase 2 isoform 2
• NCBI Official Synonym Full Names: homeodomain interacting protein kinase 2
• NCBI Official Symbol: HIPK2
• NCBI Official Synonym Symbols: PRO0593
• NCBI Protein Information: homeodomain-interacting protein kinase 2
• UniProt Protein Name: Homeodomain-interacting protein kinase 2
• Protein Family: Homeodomain-interacting protein kinase
• UniProt Gene Name: HIPK2
• UniProt Synonym Gene Names: hHIPk2

NCBI Description

This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis.